{"id":"W3156444602","doi":"10.1016/j.cmet.2021.03.023","title":"Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment","year":2021,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":285,"is_retracted":false,"has_abstract":false,"ca_institutions":"Juravinski Cancer Centre; Population Health Research Institute; University of Waterloo; McMaster University; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research","keywords":"Tumor microenvironment; Cancer immunotherapy; Immune system; Immunotherapy; Biology; Cancer research; Cancer cell; Cancer; Cell metabolism; Immunology; Cell; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004341795,0.0002712773,0.0003679632,0.0001141397,0.000312096,0.00004685178,0.0002505908,0.0001431391,0.005584392],"category_scores_gemma":[0.00003464066,0.000208069,0.0002344717,0.000211245,0.0001456162,0.0001607045,0.0001091509,0.0005539907,0.001710066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003422401,"about_ca_system_score_gemma":0.00004928538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007316464,"about_ca_topic_score_gemma":0.0000227859,"domain_scores_codex":[0.9978327,0.0006799999,0.000496722,0.0005002751,0.00008065708,0.000409615],"domain_scores_gemma":[0.9990384,0.0001039221,0.0001637611,0.0006087516,0.00006213672,0.0000230206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004563143,0.0005118967,0.0006660268,0.00002009025,0.00002898031,0.0000176554,0.0004067785,0.0000203711,0.991685,0.0002951056,0.005798902,0.0005035377],"study_design_scores_gemma":[0.0009173498,0.00001536601,0.04523076,0.000004537057,0.00006425197,0.00007214055,0.0005265553,0.000002404345,0.5456603,0.0000845721,0.4072782,0.0001436142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.963322,0.0232712,0.00009696034,0.0002261597,0.004756966,0.0002528764,0.00001498848,0.0000442169,0.008014591],"genre_scores_gemma":[0.9621494,0.0003070081,0.00005253138,0.001474455,0.0001468455,0.0000706678,0.0003196362,0.00002364877,0.03545583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4460248,"threshold_uncertainty_score":0.9990672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01962568506950791,"score_gpt":0.2322868589590845,"score_spread":0.2126611738895766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}