{"id":"W3156444602","doi":"10.1016/j.cmet.2021.03.023","title":"Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment","year":2021,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":285,"is_retracted":false,"has_abstract":false,"ca_institutions":"Juravinski Cancer Centre; Population Health Research Institute; University of Waterloo; McMaster University; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research","keywords":"Tumor microenvironment; Cancer immunotherapy; Immune system; Immunotherapy; Biology; Cancer research; Cancer cell; Cancer; Cell metabolism; Immunology; Cell; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007684024,0.00008448832,0.0001264212,0.0001474623,0.0001579763,0.0006206163,0.00007956102,0.0001506369,0.001672937],"category_scores_gemma":[0.0001520932,0.0001010786,0.00009046533,0.0001515607,0.0001805105,0.0002543106,0.0002004889,0.0001685316,0.0002591034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000194562,"about_ca_system_score_gemma":0.0001023149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004743297,"about_ca_topic_score_gemma":0.0007400062,"domain_scores_codex":[0.999929,0.00001905404,0.000003720635,0.00001621763,0.000009329382,0.00002280111],"domain_scores_gemma":[0.9999512,0.00001316797,0.00001100254,0.000005636213,0.000006316029,0.00001269195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001658373,0.00002617991,0.01767456,0.00002083203,0.00001570906,0.0001390615,0.0001082012,0.0004746112,0.9736596,0.0005086266,0.00007801861,0.005636237],"study_design_scores_gemma":[0.00005692849,0.0006374816,0.3142641,0.00001979779,0.00006023534,0.001589726,0.001325253,0.005776425,0.6705872,0.001817956,0.003826451,0.00003832539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988399,0.0002652343,0.0002448823,0.00003201908,0.000003063993,0.000001260967,0.00007206046,0.000002625563,0.000538883],"genre_scores_gemma":[0.9996532,0.00007498081,0.00004658178,0.000005845676,0.000001192648,0.000001252539,0.00005145591,0.000002885852,0.0001626017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001672937,"threshold_uncertainty_score":0.005596459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01962568506950791,"score_gpt":0.2322868589590845,"score_spread":0.2126611738895766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}