{"id":"W3156454816","doi":"","title":"The Role of Modified Fc Fragments in Treating Autoimmune Diseases: A Potential Replacement for Intravenous Immunoglobulin","year":2020,"lang":"en","type":"dissertation","venue":"TSpace","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health Canada; Canadian Blood Services; Australian Government; Government of Canada; CSL Behring","keywords":"Antibody; Intravenous Immunoglobulins; Medicine; Immunology; Fragment crystallizable region","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002262024,0.0003016769,0.0002275357,0.0002751723,0.00006624284,0.0002890418,0.0003609784,0.0005437961,0.0006321275],"category_scores_gemma":[0.0001364627,0.00006971071,0.0002233972,0.000188601,0.0002606363,0.0002961454,0.0001459419,0.0006645771,0.0002299058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002307733,"about_ca_system_score_gemma":0.0001616392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003169393,"about_ca_topic_score_gemma":0.0002611682,"domain_scores_codex":[0.9999317,0.00001427027,0.000003874235,0.00001311406,0.00002342947,0.00001347799],"domain_scores_gemma":[0.9999559,0.00001104456,0.00001349523,0.000003908762,0.000006272658,0.000009380711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001381191,0.0003503053,0.0009946746,0.001109666,0.00005330856,0.0007246981,0.00008259986,0.0007279711,0.6315179,0.00377739,0.00296766,0.3563126],"study_design_scores_gemma":[0.0005895212,0.01274924,0.01041618,0.0003251193,0.0003447545,0.007535404,0.00007573789,0.003061936,0.7088085,0.003314791,0.2527125,0.0000661961],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.2740493,0.6994362,0.01422281,0.004989241,0.0006809865,0.0001039147,0.0002041006,0.0001938815,0.00611958],"genre_scores_gemma":[0.7463759,0.2304043,0.01330632,0.001705314,0.0007579697,0.00009690929,0.0002627799,0.00003153387,0.007058919],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.0006321275,"threshold_uncertainty_score":0.002114713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01351964376302822,"score_gpt":0.338774145195099,"score_spread":0.3252545014320708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}