{"id":"W3156709539","doi":"10.3389/fphys.2021.673404","title":"Evolving Roles of Muscle-Resident Fibro-Adipogenic Progenitors in Health, Regeneration, Neuromuscular Disorders, and Aging","year":2021,"lang":"en","type":"review","venue":"Frontiers in Physiology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Comisión Nacional de Investigación Científica y Tecnológica; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Centro de Envejecimiento y Regeneración, Pontificia Universidad Católica de Chile; Victor Chang Cardiac Research Institute; Michael Smith Health Research BC; European Molecular Biology Organization","keywords":"Regeneration (biology); Adipogenesis; Sarcopenia; Progenitor cell; Biology; Medicine; Skeletal muscle; Neuroscience; Cell biology; Physical medicine and rehabilitation; Bioinformatics; Gerontology; Stem cell; Anatomy; Endocrinology; Adipose tissue","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000283006,0.000429357,0.001548375,0.0002954398,0.00007278244,0.00001024392,0.0003006109,0.0005137655,0.000009814497],"category_scores_gemma":[0.0001463715,0.0004353236,0.0003277358,0.0003108963,0.0002326704,0.000009395872,0.0002557593,0.0003444937,6.262593e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004593374,"about_ca_system_score_gemma":0.0004475211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001101702,"about_ca_topic_score_gemma":0.0003614638,"domain_scores_codex":[0.9966331,0.0009992953,0.0008769431,0.0009205805,0.00009522133,0.0004748668],"domain_scores_gemma":[0.9988602,0.00003792874,0.0004357609,0.0005456216,0.00004152642,0.00007899561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007447415,0.0003243644,0.001928151,0.01710518,0.0005475353,0.00001027046,0.0003640953,0.0006514124,0.008736215,0.0001354335,0.006781099,0.9633418],"study_design_scores_gemma":[0.001799736,0.0008001682,0.006376193,0.00672313,0.0002539509,0.00002148138,0.0006860419,0.000206451,0.0005175201,0.001874052,0.9791207,0.001620589],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01125099,0.9873619,0.0001556663,0.00006275535,0.0005152594,0.000607395,0.00002132298,0.000007763137,0.00001694047],"genre_scores_gemma":[0.006988915,0.9912179,0.0006273566,0.00006304168,0.0001594019,0.0001443232,0.0007054159,0.00005481658,0.00003884194],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9723396,"threshold_uncertainty_score":0.9998099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009317083527811775,"score_gpt":0.2691240634210298,"score_spread":0.259806979893218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}