{"id":"W3156730503","doi":"10.21203/rs.3.rs-374466/v1","title":"The Safety, Efficacy, and Tolerability of Microbial Ecosystem Therapeutic-2 in People With Major Depressive Disorder and/or Generalized Anxiety Disorder: A Phase 1, Open-Label Study","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Tolerability; Anxiety; Adverse effect; Generalized anxiety disorder; Microbiome; Randomized controlled trial; Major depressive disorder; Medicine; Internal medicine; Clinical trial; Depression (economics); Psychiatry; Bioinformatics; Mood; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00184535,0.0007335352,0.00128639,0.0002706012,0.000375474,0.0005005663,0.0004227764,0.0009281695,0.002384969],"category_scores_gemma":[0.0009197811,0.0004004232,0.0009895251,0.0002045309,0.0005568603,0.0005424326,0.0003083242,0.001567991,0.0003461653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003353876,"about_ca_system_score_gemma":0.0006174474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003934263,"about_ca_topic_score_gemma":0.0010686,"domain_scores_codex":[0.9994735,0.0002945358,0.00003926571,0.00006073703,0.0000589565,0.00007295391],"domain_scores_gemma":[0.9994617,0.0001230855,0.0001595197,0.00005033815,0.00004913888,0.0001562354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7331336,0.1354575,0.009433395,0.001201147,0.001398807,0.0001628701,0.000360575,0.0006010616,0.03428349,0.0001098506,0.001016985,0.0828409],"study_design_scores_gemma":[0.292695,0.6886104,0.01505954,0.00003433547,0.0003704586,0.00009328952,0.00007080144,0.0004681661,0.001923327,0.00005627648,0.0006012619,0.0000173205],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971999,0.0007532293,0.0002649037,0.0001023815,0.00003571319,0.001087205,0.0002064217,0.00001999896,0.0003302689],"genre_scores_gemma":[0.9952073,0.000778411,0.001079322,0.0003705773,0.0001116609,0.001573769,0.0002697216,0.000005252278,0.0006041261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002384969,"threshold_uncertainty_score":0.009759247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03831168292857794,"score_gpt":0.3955280266002777,"score_spread":0.3572163436716998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}