{"id":"W3156734844","doi":"10.1002/mds.28612","title":"Retinal Architecture in Autosomal Recessive Spastic Ataxia of Charlevoix‐Saguenay <scp>(ARSACS)</scp>: Insights into Disease Pathogenesis and Biomarkers","year":2021,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute for Health and Care Research","keywords":"Medicine; Ophthalmology; Spinocerebellar ataxia; Retinal; Nerve fiber layer; Hereditary spastic paraplegia; Pathology; Disease; Phenotype; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003425706,0.0003754731,0.0002192704,0.001402909,0.0002699217,0.0003041936,0.0001638302,0.0002774958,0.0008548647],"category_scores_gemma":[0.0004407054,0.0001399683,0.0001662007,0.0006317249,0.0003059061,0.000180738,0.0002156398,0.0001384392,0.0001074234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000421907,"about_ca_system_score_gemma":0.0002009852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004783578,"about_ca_topic_score_gemma":0.005786871,"domain_scores_codex":[0.9998643,0.00002943918,0.00001840554,0.00003753433,0.00002981189,0.00002057216],"domain_scores_gemma":[0.999689,0.00004761688,0.0001561403,0.00001373532,0.00005597679,0.00003750714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006745274,0.00005234646,0.9589997,0.0001050412,0.0001224931,0.004850904,0.0002452878,0.0002583736,0.02382689,0.00008913983,0.0001853007,0.01059006],"study_design_scores_gemma":[0.0000110801,0.0001697166,0.988243,0.00001525054,0.00004257836,0.009444659,0.0001168285,0.0003791132,0.00125549,0.00004344163,0.0002748202,0.000003917458],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991146,0.00048691,0.0000989737,0.00001194784,0.000001210362,0.000004322099,0.00004683872,0.000005222035,0.0002299852],"genre_scores_gemma":[0.9995643,0.0001270615,0.0001590699,0.000008974723,0.000001787408,0.000002996038,0.00006455641,8.861738e-7,0.00007029714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004783578,"threshold_uncertainty_score":0.009511471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01010787457115109,"score_gpt":0.2289032538274362,"score_spread":0.2187953792562851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}