{"id":"W3156734844","doi":"10.1002/mds.28612","title":"Retinal Architecture in Autosomal Recessive Spastic Ataxia of Charlevoix‐Saguenay <scp>(ARSACS)</scp>: Insights into Disease Pathogenesis and Biomarkers","year":2021,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute for Health and Care Research","keywords":"Medicine; Ophthalmology; Spinocerebellar ataxia; Retinal; Nerve fiber layer; Hereditary spastic paraplegia; Pathology; Disease; Phenotype; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007754467,0.000363566,0.0003241138,0.0002622373,0.0001525154,0.00006042174,0.0002887276,0.00006072498,0.00003968466],"category_scores_gemma":[0.001611576,0.0003544147,0.0001195215,0.0007261549,0.0004343714,0.0001165425,0.0002888076,0.0001486268,0.000006488923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004647417,"about_ca_system_score_gemma":0.0001916005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006410247,"about_ca_topic_score_gemma":0.0005845606,"domain_scores_codex":[0.997026,0.0004952477,0.0004414036,0.001027486,0.0005560919,0.0004538005],"domain_scores_gemma":[0.9985695,0.0003769218,0.0002016162,0.0004787394,0.00006398476,0.0003091842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008467452,0.0005294122,0.1093808,0.0002332832,0.00002606629,0.0001825849,0.001362469,0.001330661,0.8826887,0.000333391,0.0005130816,0.003334896],"study_design_scores_gemma":[0.001364853,0.0001592121,0.3701749,0.0001373767,0.00006839867,7.117284e-7,0.0008060277,0.0008520107,0.6103801,0.01538304,0.0004266594,0.0002467172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952756,0.002009561,0.0006843655,0.0009624255,0.0001718911,0.0005085327,0.000102486,0.00003739627,0.0002477903],"genre_scores_gemma":[0.9968525,0.0006294082,0.0001995185,0.001862296,0.00002978819,0.0001110616,0.00003133589,0.00004386064,0.0002402117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2723086,"threshold_uncertainty_score":0.9998908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01010787457115109,"score_gpt":0.2289032538274362,"score_spread":0.2187953792562851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}