{"id":"W3156815314","doi":"10.1111/bph.15497","title":"The therapeutic potential of GLP‐1 receptor biased agonism","year":2021,"lang":"en","type":"review","venue":"British Journal of Pharmacology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Imperial Biomedical Research Centre; Biotechnology and Biological Sciences Research Council; Medical Research Council; Medical Research Council Canada; European Foundation for the Study of Diabetes; Academy of Medical Sciences; British Society for Neuroendocrinology; Society for Endocrinology; Engineering and Physical Sciences Research Council; Sunesis; National Institute for Health and Care Research","keywords":"Downregulation and upregulation; Receptor; Glucagon-like peptide-1; Glucagon-like peptide 1 receptor; Appetite; Pharmacology; Agonist; Intracellular; Functional selectivity; Signal transduction; Signalling; Biology; Bioinformatics; Type 2 diabetes; Endocrinology; Medicine; Internal medicine; Diabetes mellitus; Cell biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000603535,0.0002297275,0.00180217,0.0001477342,0.000095034,0.00004460668,0.0002943541,0.0001677107,0.0009374342],"category_scores_gemma":[0.00004396091,0.0001707688,0.001104648,0.0002065076,0.0001555079,0.00004565073,0.00008423146,0.0005706202,0.00001877494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001249437,"about_ca_system_score_gemma":0.0005469826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006005261,"about_ca_topic_score_gemma":0.000001354066,"domain_scores_codex":[0.9977293,0.0004507715,0.001025877,0.0001724977,0.0003190792,0.0003024912],"domain_scores_gemma":[0.9981256,0.0002543165,0.001100442,0.0001066484,0.0002987878,0.0001142133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003673088,0.000356463,6.306789e-7,0.001990942,0.004480675,0.001866526,0.000006162162,3.716977e-7,0.0001894326,0.00002212058,0.05884833,0.9322016],"study_design_scores_gemma":[0.002019923,0.0004591011,0.000007624405,0.006293341,0.01190744,0.002860691,0.00002152077,0.000001124483,0.0001399867,0.00001218624,0.9761613,0.0001157388],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001413149,0.9955572,0.00001824632,0.0003948177,0.002958348,0.0005653395,0.00002465178,0.000007861407,0.0003321563],"genre_scores_gemma":[0.0002037028,0.996664,0.0001251714,0.0003000933,0.0009848139,0.00002457508,0.00004545963,0.00004215601,0.001610062],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9320859,"threshold_uncertainty_score":0.9999759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03835100197603851,"score_gpt":0.3596929980729513,"score_spread":0.3213419960969128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}