{"id":"W3156815314","doi":"10.1111/bph.15497","title":"The therapeutic potential of GLP‐1 receptor biased agonism","year":2021,"lang":"en","type":"review","venue":"British Journal of Pharmacology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Imperial Biomedical Research Centre; Biotechnology and Biological Sciences Research Council; Medical Research Council; Medical Research Council Canada; European Foundation for the Study of Diabetes; Academy of Medical Sciences; British Society for Neuroendocrinology; Society for Endocrinology; Engineering and Physical Sciences Research Council; Sunesis; National Institute for Health and Care Research","keywords":"Downregulation and upregulation; Receptor; Glucagon-like peptide-1; Glucagon-like peptide 1 receptor; Appetite; Pharmacology; Agonist; Intracellular; Functional selectivity; Signal transduction; Signalling; Biology; Bioinformatics; Type 2 diabetes; Endocrinology; Medicine; Internal medicine; Diabetes mellitus; Cell biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004796213,0.0003067349,0.0004707254,0.0003673689,0.0001392084,0.0009353114,0.0004157844,0.0007516315,0.003788537],"category_scores_gemma":[0.0004723541,0.0001186213,0.0004722934,0.0001735503,0.000421051,0.0007879558,0.0006278349,0.002205493,0.001265939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003465929,"about_ca_system_score_gemma":0.0002979005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001350282,"about_ca_topic_score_gemma":0.0002506012,"domain_scores_codex":[0.9997969,0.00005948701,0.00001309513,0.00003708319,0.00005970059,0.00003371485],"domain_scores_gemma":[0.9998848,0.00005600132,0.00001872042,0.000005610275,0.00002007171,0.00001484676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001152152,0.0002069465,0.0005880329,0.008140262,0.00015333,0.001139649,0.0002510815,0.001188057,0.1581963,0.04497253,0.02883564,0.7551761],"study_design_scores_gemma":[0.0001753325,0.00177445,0.002036148,0.00167884,0.0002086144,0.003840316,0.000197117,0.0008252151,0.03947617,0.02352108,0.9261997,0.00006709561],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02101337,0.9254153,0.01009114,0.01048795,0.003033752,0.00005397085,0.0002420202,0.0001896986,0.02947286],"genre_scores_gemma":[0.1402735,0.8245798,0.006827536,0.01130526,0.00294656,0.0001373959,0.0003355635,0.00008101692,0.01351335],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003788537,"threshold_uncertainty_score":0.01267391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03835100197603851,"score_gpt":0.3596929980729513,"score_spread":0.3213419960969128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}