{"id":"W3156921230","doi":"10.3389/fphy.2021.654613","title":"Mechanotransduction of Strain Regulates an Invasive Phenotype in Newly Transformed Epithelial Cells","year":2021,"lang":"en","type":"article","venue":"Frontiers in Physics","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; LightMachinery (Canada); University of Ottawa","funders":"Hokkaido University; Canada Foundation for Innovation; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Mechanotransduction; Cell biology; Phenotype; Actin; Biology; Adhesion; Chemistry; Focal adhesion; Strain (injury); Epithelium; Anatomy; Signal transduction; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008107499,0.0001071385,0.0001641796,0.00004118322,0.00001965218,0.000008771092,0.0000937753,0.0001100198,0.00001489233],"category_scores_gemma":[0.0000128806,0.00012341,0.00008023969,0.0001732741,0.00002708709,0.00001408347,0.00001435742,0.0001054741,7.434836e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000236812,"about_ca_system_score_gemma":0.0001272955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003659837,"about_ca_topic_score_gemma":0.0002466167,"domain_scores_codex":[0.9992393,0.00005945439,0.00020958,0.0002503944,0.00008325121,0.0001579888],"domain_scores_gemma":[0.9996282,0.000004426979,0.00005245845,0.000214611,0.00006502804,0.00003530562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005699879,0.0001913887,0.00007452702,0.00002286055,0.00002504145,0.000003610255,0.000364909,0.0009160889,0.9865848,0.0006136106,0.0001389006,0.01100731],"study_design_scores_gemma":[0.0005858777,0.0001233714,0.0001075466,0.0000201915,0.00001223242,0.000001456034,0.0007973063,0.00109446,0.986196,0.009865968,0.001067151,0.000128458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9092464,0.0002602115,0.08885352,0.00006061233,0.0009979304,0.0001570135,0.0001128719,0.000004978072,0.0003064416],"genre_scores_gemma":[0.9932756,0.0003891482,0.005568698,0.0000448179,0.0001817114,0.000009122834,0.000380356,0.00001944979,0.0001311198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08402915,"threshold_uncertainty_score":0.5032514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007978909345203542,"score_gpt":0.2204841138340193,"score_spread":0.2125052044888158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}