{"id":"W3156921230","doi":"10.3389/fphy.2021.654613","title":"Mechanotransduction of Strain Regulates an Invasive Phenotype in Newly Transformed Epithelial Cells","year":2021,"lang":"en","type":"article","venue":"Frontiers in Physics","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; LightMachinery (Canada); University of Ottawa","funders":"Hokkaido University; Canada Foundation for Innovation; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Mechanotransduction; Cell biology; Phenotype; Actin; Biology; Adhesion; Chemistry; Focal adhesion; Strain (injury); Epithelium; Anatomy; Signal transduction; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005143192,0.0001266864,0.0001281126,0.0001373258,0.000136162,0.0002693946,0.0001120556,0.0001470012,0.0008638976],"category_scores_gemma":[0.00007264843,0.0001174049,0.0001466473,0.00009884874,0.0001799571,0.0001491289,0.0001780882,0.000276,0.0001619502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001898962,"about_ca_system_score_gemma":0.0001005879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003540222,"about_ca_topic_score_gemma":0.0004470929,"domain_scores_codex":[0.9999266,0.000009789383,0.000004669275,0.00001140542,0.00002585515,0.00002171652],"domain_scores_gemma":[0.9999311,0.00001430579,0.000020128,0.000008390006,0.00000850268,0.000017543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002279664,0.00001079128,0.0001479924,0.00000655992,0.000001050556,0.00003261746,0.00001244976,0.00003382825,0.999286,0.00008092108,0.0000105195,0.0003545258],"study_design_scores_gemma":[0.000006930194,0.0001457121,0.0201201,0.000003078354,0.000005099625,0.0001993537,0.0001018944,0.002185175,0.9762341,0.000131696,0.0008605024,0.000006234228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997842,0.0002363463,0.001039004,0.00003971942,0.000009471747,0.000004747166,0.00005536179,0.00002965763,0.0007437236],"genre_scores_gemma":[0.9988287,0.00017397,0.0003683744,0.00001369017,0.000002866965,0.000006405326,0.00004865348,0.000006422962,0.0005509192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008638976,"threshold_uncertainty_score":0.00289005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007978909345203542,"score_gpt":0.2204841138340193,"score_spread":0.2125052044888158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}