{"id":"W3156991280","doi":"10.3390/pharmaceutics13040577","title":"The Impact of an Efflux Pump Inhibitor on the Activity of Free and Liposomal Antibiotics against Pseudomonas aeruginosa","year":2021,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"","keywords":"Pseudomonas aeruginosa; Liposome; Efflux; Cystic fibrosis; Pyocyanin; Microbiology; Antibiotics; Biofilm; Chemistry; Gentamicin; Antimicrobial; Erythromycin; Minimum inhibitory concentration; Tobramycin; Pharmacology; Quorum sensing; Bacteria; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001712179,0.0002242602,0.0003070751,0.0001056206,0.00006721963,0.0002382212,0.0001532957,0.0001808431,0.0006419396],"category_scores_gemma":[0.0002931665,0.00008160255,0.0001274169,0.00006855342,0.0001258069,0.0003421775,0.0001989538,0.0002530352,0.0001048318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001209125,"about_ca_system_score_gemma":0.0001288327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000272776,"about_ca_topic_score_gemma":0.0004295224,"domain_scores_codex":[0.9998468,0.00005674576,0.00001305586,0.00002519019,0.00003699302,0.0000211504],"domain_scores_gemma":[0.9999012,0.00003742234,0.00002237362,0.000007111864,0.00001625449,0.00001563553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000703125,0.0001516365,0.0002301666,0.0001263352,0.000017193,0.00003082072,0.00001569114,0.0001363366,0.9914443,0.00003750661,0.00004316577,0.007063918],"study_design_scores_gemma":[0.00008248579,0.006960616,0.006355592,0.00002387084,0.00009874526,0.0001887193,0.00004115192,0.001697419,0.9819179,0.00003239547,0.002587182,0.00001384444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994728,0.004024735,0.0005601086,0.00005304172,0.00001693551,0.00002098194,0.00005453425,0.00001218001,0.0005294413],"genre_scores_gemma":[0.9970022,0.001472534,0.000763593,0.00003331376,0.000009253386,0.00001768948,0.00006597433,0.000005959116,0.0006294003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006419396,"threshold_uncertainty_score":0.002147496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0228797862800702,"score_gpt":0.3062627282372891,"score_spread":0.2833829419572189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}