{"id":"W3157019502","doi":"10.1016/j.jaip.2021.04.015","title":"The Importance of a Timely Second Dose of the 2021 COVID-19 mRNA Vaccine Depends on the Protection Afforded by a First Dose and Subsequent Risk of Anaphylaxis","year":2021,"lang":"en","type":"article","venue":"The Journal of Allergy and Clinical Immunology In Practice","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; University of Alberta; University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Human Genome Research Institute; Medical Research Council; Sanofi Genzyme; Genentech; European Academy of Allergy and Clinical Immunology; Regeneron Pharmaceuticals; National Institutes of Health; National Health and Medical Research Council; AstraZeneca; Allergy Therapeutics; National Peanut Board; Aimmune Therapeutics; Novartis; BioCryst; Pfizer; Institute for Health Metrics and Evaluation; Covis Pharma; Food Allergy Canada; Australasian Society of Clinical Immunology and Allergy; Sanofi; GlaxoSmithKline; Bausch Health","keywords":"Vaccination; Medicine; Pandemic; Immunology; Population; Intensive care medicine; Disease; Coronavirus disease 2019 (COVID-19); Environmental health; Infectious disease (medical specialty); Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001647709,0.0004730517,0.0005120824,0.0001224462,0.0002589654,0.0006192166,0.0002196947,0.001198481,0.004412576],"category_scores_gemma":[0.006286392,0.0001727233,0.0005279658,0.00007769628,0.0002722273,0.0007365713,0.0002476316,0.001996586,0.0007834746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003770821,"about_ca_system_score_gemma":0.0007329792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004469318,"about_ca_topic_score_gemma":0.0004874843,"domain_scores_codex":[0.99901,0.0003652055,0.00007515864,0.0001038214,0.000243965,0.0002018411],"domain_scores_gemma":[0.9950211,0.002957102,0.001010441,0.0002822601,0.0003463656,0.0003827102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.03030947,0.005256762,0.2795248,0.002202424,0.0006198018,0.006680585,0.0007803315,0.003576151,0.1740904,0.004335062,0.01157197,0.4810522],"study_design_scores_gemma":[0.001085268,0.06837155,0.7544317,0.001612632,0.001124804,0.0272671,0.001000246,0.006857716,0.07540406,0.005907088,0.05682095,0.0001169437],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9561271,0.01104719,0.005502605,0.005170916,0.001086882,0.0002768463,0.0001774493,0.00009998569,0.02051103],"genre_scores_gemma":[0.9944152,0.001481371,0.00142622,0.0007688829,0.0004470794,0.00004309122,0.00007182941,0.00001374848,0.001332673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004412576,"threshold_uncertainty_score":0.01476151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04010510160182854,"score_gpt":0.3712959980404921,"score_spread":0.3311908964386636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}