{"id":"W3157022736","doi":"10.3390/vaccines9050467","title":"Efficacy and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis of Randomized Clinical Trials","year":2021,"lang":"en","type":"review","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":352,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Immunogenicity; Adjuvant; Adverse effect; Placebo; Internal medicine; Randomized controlled trial; Coronavirus disease 2019 (COVID-19); Clinical trial; Meta-analysis; Immune system; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01667757,0.0029547,0.020035,0.007868431,0.0006182763,0.00320988,0.001968926,0.001972852,0.003879229],"category_scores_gemma":[0.04125245,0.001517571,0.03218683,0.0088514,0.0007438294,0.001818367,0.001523404,0.001826765,0.0003406181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002812423,"about_ca_system_score_gemma":0.00435631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004963142,"about_ca_topic_score_gemma":0.01005522,"domain_scores_codex":[0.9831442,0.007674414,0.005546477,0.001608661,0.001623557,0.0004026856],"domain_scores_gemma":[0.9717509,0.02090984,0.004464685,0.0008531242,0.001742173,0.0002794008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002087973,0.00002189464,0.003697741,0.4868353,0.4932624,0.00009916858,0.00007215287,0.0004210468,0.0002348723,0.0001645657,0.0006700244,0.01243285],"study_design_scores_gemma":[0.0007169038,0.0001929943,0.003263672,0.03319563,0.9600667,0.00009075158,0.00003611546,0.0001292204,0.0001246332,0.0002177619,0.001944414,0.00002116498],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003633596,0.9941703,0.0005453844,0.0001997586,0.0001346248,0.000296345,0.0007864091,0.00002155365,0.0002122057],"genre_scores_gemma":[0.1457937,0.8455188,0.003427353,0.00118579,0.000363354,0.001669843,0.001670782,0.00004495649,0.0003253339],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.020035,"threshold_uncertainty_score":0.08820051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3552466344806727,"score_gpt":0.5440322862008313,"score_spread":0.1887856517201586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}