{"id":"W3157029763","doi":"10.1371/journal.pbio.3001221","title":"Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough","year":2021,"lang":"en","type":"article","venue":"PLoS Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; E-Rare","keywords":"Biology; Protein biosynthesis; Molecular biology; Ribosome; Ribosomal protein s6; Ribosome biogenesis; Translation (biology); Cell biology; Puromycin; Ribosomal protein; Messenger RNA; RNA; Biochemistry; Gene; Signal transduction; P70-S6 Kinase 1; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001092848,0.0003631567,0.0003642317,0.0002111716,0.0001031874,0.0001932419,0.00009948705,0.0002455036,0.001251156],"category_scores_gemma":[0.0001196948,0.0001121072,0.0002689207,0.0001472663,0.0001425821,0.0001120699,0.0001710443,0.0003818838,0.0003218401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002258714,"about_ca_system_score_gemma":0.0001618122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002798028,"about_ca_topic_score_gemma":0.0006108554,"domain_scores_codex":[0.9998986,0.00001845397,0.000008752576,0.00001658778,0.00002991399,0.00002776617],"domain_scores_gemma":[0.99991,0.00001933067,0.00003128389,0.000006646174,0.000008838882,0.00002400713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001294332,0.00003863135,0.0001541453,0.00004129476,0.000003992744,0.00003886172,0.000005270086,0.00006697894,0.9979607,0.00002256474,0.00006432996,0.00147379],"study_design_scores_gemma":[0.0000604399,0.0015324,0.004932575,0.000009058713,0.00001360844,0.000224881,0.00001639805,0.0007748364,0.9901993,0.00002522424,0.00220634,0.000004985517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994585,0.002273004,0.0009703119,0.0001095976,0.000028077,0.00005364922,0.0004083144,0.000126185,0.001445877],"genre_scores_gemma":[0.9942318,0.001477806,0.001496167,0.00008721954,0.00001558942,0.00007101171,0.0007872613,0.00002244217,0.001810684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001251156,"threshold_uncertainty_score":0.004185557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02525355231232541,"score_gpt":0.2467232139744669,"score_spread":0.2214696616621415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}