{"id":"W3157127000","doi":"10.1016/j.coph.2021.04.006","title":"Organotypic human ex vivo models for coronavirus disease 2019 research and drug development","year":2021,"lang":"en","type":"review","venue":"Current Opinion in Pharmacology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Vetenskapsrådet; Ontario Institute for Cancer Research; Svenska Sällskapet för Medicinsk Forskning; European Commission; McGill University; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Kungliga Tekniska Högskolan; Knut och Alice Wallenbergs Stiftelse; Eli Lilly and Company","keywords":"Ex vivo; Virology; Coronavirus disease 2019 (COVID-19); Drug development; Drug; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Coronavirus; Drug discovery; Medicine; In vivo; Biology; Computational biology; Disease; Pharmacology; Bioinformatics; Infectious disease (medical specialty); Genetics; Pathology; Outbreak","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001399806,0.0004806014,0.001615128,0.0009808583,0.0002331794,0.0000491474,0.0004268747,0.0002666614,0.0001404005],"category_scores_gemma":[0.0001089509,0.0004330204,0.0002262806,0.0007026148,0.0003046401,0.00009193688,0.0006437789,0.001471709,0.00007997391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007813934,"about_ca_system_score_gemma":0.004198352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001434139,"about_ca_topic_score_gemma":0.000003599547,"domain_scores_codex":[0.9957644,0.0006299473,0.0009222974,0.001108782,0.000630955,0.0009436196],"domain_scores_gemma":[0.9979386,0.000817141,0.0001625003,0.0003854559,0.0004533863,0.0002429381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002997549,0.001412067,0.0002381975,0.07374597,0.0002769129,0.00005272837,0.0002739785,4.052625e-7,0.00009889127,0.0009180245,0.06512345,0.8575596],"study_design_scores_gemma":[0.002350053,0.0001069553,0.00001729981,0.009521422,0.0001807644,0.0000185971,0.00001874762,0.00007220938,0.0001381451,0.0002799484,0.9869383,0.0003575331],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004891916,0.9911795,0.00006329164,0.0001202493,0.003938167,0.003970515,0.0001084588,0.00004121575,0.00008938018],"genre_scores_gemma":[0.00004489168,0.9951035,0.00006079799,0.0004855424,0.001192379,0.002317375,0.0004540974,0.0001003291,0.0002410306],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9218149,"threshold_uncertainty_score":0.9998122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4466097250239165,"score_gpt":0.5820684416303749,"score_spread":0.1354587166064583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}