{"id":"W3157174551","doi":"10.1210/jendso/bvab048.002","title":"A Phase 3 Trial in Participants With Obesity Due to Bardet-Biedl Syndrome or Alström Syndrome: Efficacy and Safety of the Melanocortin 4 Receptor Agonist Setmelanotide","year":2021,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Body mass index; Internal medicine; Clinical endpoint; Obesity; Pediatrics; Randomized controlled trial; Placebo; Confidence interval; Weight loss; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002448055,0.001249421,0.001856186,0.0002478522,0.0004934568,0.0007848275,0.0005957891,0.001600052,0.009195128],"category_scores_gemma":[0.001787128,0.0004405622,0.002014162,0.000215522,0.0005532776,0.0006399939,0.0003621367,0.002715905,0.0009488984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005893467,"about_ca_system_score_gemma":0.001293528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005389269,"about_ca_topic_score_gemma":0.001463379,"domain_scores_codex":[0.9993901,0.0003415702,0.00004080782,0.00009450021,0.0000533996,0.00007960683],"domain_scores_gemma":[0.9990847,0.000262525,0.0002061292,0.00005761835,0.00008757292,0.0003014753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9601376,0.008962584,0.001416711,0.001020556,0.001419537,0.0001087994,0.0000778192,0.0003561221,0.006341659,0.0001675326,0.001734134,0.01825711],"study_design_scores_gemma":[0.9147952,0.08068966,0.002288378,0.00006041722,0.000355973,0.00007187804,0.00001577786,0.0002917013,0.0004837007,0.0001516028,0.0007824492,0.00001326184],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97992,0.003951914,0.001020088,0.001045202,0.0004972686,0.008336744,0.002161116,0.0001368257,0.002930796],"genre_scores_gemma":[0.9755402,0.001573757,0.00284817,0.001892257,0.0003053205,0.01349478,0.001812324,0.00003161471,0.002501622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009195128,"threshold_uncertainty_score":0.03076077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01344281928366585,"score_gpt":0.2807673202702574,"score_spread":0.2673245009865916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}