{"id":"W3157202223","doi":"10.1101/2020.06.18.159806","title":"SLAP2 adaptor binding disrupts c-CBL autoinhibition to activate ubiquitin ligase function","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"Garron Family Cancer Centre; Canadian Institutes of Health Research; Cancer Research Society; American Brain Tumor Association","keywords":"Ubiquitin ligase; Signal transducing adaptor protein; SH2 domain; Ubiquitin; Cell biology; Tyrosine kinase; Chemistry; DNA ligase; Receptor tyrosine kinase; Biochemistry; Biology; Signal transduction; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001965082,0.0003602382,0.0002665854,0.0002370736,0.0002753106,0.0003502941,0.0005239934,0.0004134334,0.003589366],"category_scores_gemma":[0.0001320373,0.0001889653,0.0003016347,0.0002165992,0.0003102846,0.0001397269,0.0002900212,0.0009036659,0.0008338224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001093445,"about_ca_system_score_gemma":0.0004105371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002255589,"about_ca_topic_score_gemma":0.002410147,"domain_scores_codex":[0.999673,0.0000504904,0.00003908187,0.00004601432,0.00009087224,0.0001004319],"domain_scores_gemma":[0.9997728,0.0000469087,0.00004305755,0.00003267633,0.00001517996,0.0000894394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002051805,0.00009626084,0.0001094591,0.00002067811,0.000008611957,0.00008321296,0.000007921028,0.0001477036,0.998849,0.0001282026,0.00008914294,0.0002546474],"study_design_scores_gemma":[0.00005986036,0.0001455676,0.002257604,0.000005613295,0.000006477922,0.0001744269,0.00002293604,0.002748357,0.992935,0.00004521916,0.001591503,0.000007308533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966339,0.0004086346,0.001016655,0.0001238891,0.00003979123,0.00002563695,0.0005963876,0.00009116018,0.001063929],"genre_scores_gemma":[0.9975709,0.00008322815,0.0005964075,0.00005810909,0.000004330477,0.00002311213,0.0004725056,0.00001711054,0.001174212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003589366,"threshold_uncertainty_score":0.01200759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01858276875580095,"score_gpt":0.2299448778296221,"score_spread":0.2113621090738211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}