{"id":"W3157240979","doi":"10.1111/imcb.12475","title":"Induction of stable human FOXP3<sup>+</sup> Tregs by a parasite‐derived TGF‐β mimic","year":2021,"lang":"en","type":"article","venue":"Immunology and Cell Biology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"BC Children's Hospital; Wellcome Trust; Medical Research Council; Kenneth Rainin Foundation","keywords":"FOXP3; Immune system; Immunology; IL-2 receptor; Biology; Immune tolerance; Regulatory T cell; Transforming growth factor; Proinflammatory cytokine; Heligmosomoides polygyrus; Inflammation; Cell biology; T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001860287,0.0002811876,0.0005388116,0.0001691408,0.0003469823,0.00001089274,0.0001668846,0.0008755192,0.003425862],"category_scores_gemma":[0.00005443389,0.0002726094,0.0001314933,0.0001812849,0.000671086,0.0001362635,0.0001301007,0.0006147283,0.00028175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004277094,"about_ca_system_score_gemma":0.0000694085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002910817,"about_ca_topic_score_gemma":0.00001443031,"domain_scores_codex":[0.9977877,0.0006401971,0.0005422684,0.0005339719,0.00002096999,0.0004748573],"domain_scores_gemma":[0.9990003,0.0001497198,0.0002710541,0.0003901966,0.0001660071,0.0000227891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000322009,0.0003059529,0.00158819,0.0000220928,0.000321298,0.000003320854,0.0004747867,0.000004112746,0.9873372,0.000708624,0.005999393,0.002913004],"study_design_scores_gemma":[0.002155585,0.0006179534,0.001387368,0.00001619793,0.00007336007,0.0001708725,0.001911123,0.000005615967,0.8502551,0.0002271507,0.1429436,0.0002359775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731856,0.01878144,0.0001678431,0.0002700705,0.001578335,0.0001554389,0.00002605919,0.0000747083,0.005760526],"genre_scores_gemma":[0.9780565,0.00155947,0.0000357704,0.0002326279,0.00002875754,0.00002862581,0.001172019,0.00002075856,0.01886547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1370821,"threshold_uncertainty_score":0.9999726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009901777239587245,"score_gpt":0.2288062471637823,"score_spread":0.2189044699241951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}