{"id":"W3157241006","doi":"10.1210/jendso/bvab048.1395","title":"Results From an Open-Label Extension of the Phase 2 Dose Finding Study of Once Weekly Somatrogon vs Daily Genotropin in Pediatric Patients With Growth Hormone Deficiency (GHD)","year":2021,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"OPKO Health (Canada)","funders":"","keywords":"Medicine; Vial; Cohort; Growth hormone deficiency; Open label; Adverse effect; Pediatrics; Internal medicine; Growth hormone; Surgery; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004771535,0.0002565084,0.0007358216,0.00008351461,0.0001780091,0.00003234641,0.0007630626,0.00006690952,0.000005405853],"category_scores_gemma":[0.0005384245,0.0001399958,0.0002280684,0.001110182,0.00008930426,0.0004347194,0.0004751661,0.0007425269,5.283591e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001413582,"about_ca_system_score_gemma":0.0004385383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002766109,"about_ca_topic_score_gemma":0.00002773663,"domain_scores_codex":[0.9965982,0.0002945914,0.001334753,0.0003352759,0.001098113,0.0003390423],"domain_scores_gemma":[0.9966683,0.000174136,0.001499076,0.0007145029,0.0008065633,0.0001374679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007320803,0.02673583,0.8852247,0.0001298694,0.0003550653,0.0001333338,0.01327556,0.0001139908,0.06173514,0.00001563124,0.003790351,0.001169733],"study_design_scores_gemma":[0.04869869,0.006185555,0.9344972,0.0001829249,0.0005609591,0.00003312881,0.003681105,0.0001415127,0.005783709,0.0000522491,0.00002778465,0.0001551339],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975434,0.0007296704,0.00001183785,0.0006615079,0.0002832223,0.0006523114,0.00005823047,0.000006350957,0.0000534499],"genre_scores_gemma":[0.9981244,0.0003172287,0.001083844,0.0002143286,0.0001690693,0.000003204002,0.00001191742,0.00003181567,0.00004414955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05595144,"threshold_uncertainty_score":0.5708863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03113742006409746,"score_gpt":0.3074494291549724,"score_spread":0.2763120090908749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}