{"id":"W3157254743","doi":"10.1212/wnl.94.15_supplement.950","title":"Intrathecal Drug Delivery of Antisense Oligonucleotides in Huntington’s Disease: Experience of Ionis/Roche RG6042 Development Programme and Best Practice Considerations for Real-World Use (950)","year":2020,"lang":"en","type":"article","venue":"Neurology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders; University of British Columbia","funders":"","keywords":"Intrathecal; Medicine; Huntington's disease; Oligonucleotide; Disease; Drug; Pharmacology; Pathology; Surgery; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005008428,0.0003842611,0.0002122097,0.000171278,0.0004147648,0.0008615567,0.0006128974,0.001433327,0.001816986],"category_scores_gemma":[0.002430772,0.0001329856,0.0003338633,0.000156533,0.0006105155,0.0006328307,0.000663267,0.00131985,0.001059516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005064894,"about_ca_system_score_gemma":0.0009467374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001523349,"about_ca_topic_score_gemma":0.002839781,"domain_scores_codex":[0.9991995,0.0004158275,0.00004923503,0.00006231814,0.000163172,0.0001100755],"domain_scores_gemma":[0.9992105,0.000273872,0.0001102435,0.00006381603,0.0001418725,0.0001996239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.002892511,0.003768551,0.005573989,0.0006312045,0.00009907012,0.006021298,0.003305679,0.001899587,0.1758134,0.002336322,0.01777097,0.7798875],"study_design_scores_gemma":[0.002454521,0.06907018,0.03714925,0.0006369184,0.0003616237,0.05549299,0.003201898,0.00403956,0.3349055,0.003691251,0.4887388,0.00025733],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7410083,0.1007641,0.08141248,0.02902553,0.001589248,0.001102659,0.0003221036,0.0005912443,0.04418436],"genre_scores_gemma":[0.8036111,0.05928566,0.07918434,0.01478608,0.00110973,0.0006455124,0.0006368533,0.0003821093,0.04035864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005008428,"threshold_uncertainty_score":0.02648741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07215625469858852,"score_gpt":0.3047671595801968,"score_spread":0.2326109048816083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}