{"id":"W3157276232","doi":"10.1002/onco.13804","title":"Effectiveness of Alpelisib + Fulvestrant Compared with Real-World Standard Treatment Among Patients with HR+, HER2–, <i>PIK3CA</i>-Mutated Breast Cancer","year":2021,"lang":"en","type":"article","venue":"The Oncologist","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Fulvestrant; Medicine; Internal medicine; Oncology; Aromatase inhibitor; Breast cancer; Cohort; Letrozole; Metastatic breast cancer; Palbociclib; Cancer; Clinical trial; Estrogen receptor; Aromatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001868058,0.0003518092,0.0008778638,0.00005859294,0.000134421,0.00001944528,0.0001390151,0.00005895512,0.0001422457],"category_scores_gemma":[0.00001015953,0.0001806322,0.00008863102,0.0005900406,0.0008757529,0.0001031507,0.0000376518,0.0001885545,0.000002183768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001209519,"about_ca_system_score_gemma":0.0008011834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004953731,"about_ca_topic_score_gemma":0.009819921,"domain_scores_codex":[0.9981046,0.0002848151,0.0003141922,0.0004337441,0.0004751225,0.0003875247],"domain_scores_gemma":[0.9980512,0.0002893925,0.0002886227,0.0005789495,0.0006499991,0.0001417965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04621675,0.001713558,0.926801,0.000346537,0.001465234,0.0003156424,0.0006918163,0.004451909,0.001982386,0.00008366974,0.00004289826,0.0158886],"study_design_scores_gemma":[0.016937,0.002551176,0.9616889,0.001133213,0.0005651831,0.00006694893,0.0004139588,0.00003108151,0.01582373,0.00003005012,0.0005187061,0.0002400971],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955664,0.0002774522,0.0002346544,0.0005515342,0.0001061486,0.001207746,0.0005011473,0.00009691223,0.001457963],"genre_scores_gemma":[0.9984083,0.0001105956,0.0005446876,0.00007887064,0.00006246689,0.000240272,0.0001503051,0.00005669217,0.0003477999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03488785,"threshold_uncertainty_score":0.7488592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01295471819976937,"score_gpt":0.2979926871360865,"score_spread":0.2850379689363172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}