{"id":"W3157276232","doi":"10.1002/onco.13804","title":"Effectiveness of Alpelisib + Fulvestrant Compared with Real-World Standard Treatment Among Patients with HR+, HER2–, <i>PIK3CA</i>-Mutated Breast Cancer","year":2021,"lang":"en","type":"article","venue":"The Oncologist","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Fulvestrant; Medicine; Internal medicine; Oncology; Aromatase inhibitor; Breast cancer; Cohort; Letrozole; Metastatic breast cancer; Palbociclib; Cancer; Clinical trial; Estrogen receptor; Aromatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001367657,0.0003077061,0.0007155109,0.0002829611,0.0001275561,0.0005018196,0.000381605,0.0003263695,0.001585858],"category_scores_gemma":[0.001482771,0.0001030043,0.0007648341,0.0002165938,0.000312214,0.0004027612,0.0003021383,0.0005382171,0.0001361189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007150123,"about_ca_system_score_gemma":0.0004239832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004924897,"about_ca_topic_score_gemma":0.001120666,"domain_scores_codex":[0.9992784,0.0004398644,0.00004047588,0.0001220883,0.00006151216,0.00005776962],"domain_scores_gemma":[0.9992167,0.0002429413,0.0002649735,0.00006625261,0.00003292402,0.0001761583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8090714,0.008105197,0.05698894,0.0004813693,0.002380917,0.00007384882,0.0001732525,0.002771444,0.007722756,0.0002311574,0.001217512,0.1107822],"study_design_scores_gemma":[0.2321515,0.5266736,0.2171729,0.0001436546,0.003137516,0.0006668277,0.0002348908,0.006484573,0.006912219,0.0004855315,0.005863928,0.00007292289],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998075,0.001005443,0.00008711883,0.000072966,0.00001568715,0.00007950125,0.0001854323,0.000008827534,0.0004700271],"genre_scores_gemma":[0.9988602,0.0002909595,0.0001532841,0.00005993855,0.00002182132,0.0000641486,0.000399484,0.000001749311,0.0001484941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001585858,"threshold_uncertainty_score":0.007232964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01295471819976937,"score_gpt":0.2979926871360865,"score_spread":0.2850379689363172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}