{"id":"W3157315342","doi":"10.3389/fcell.2021.652651","title":"Ceramide-Induced Lysosomal Biogenesis and Exocytosis in Early-Onset Preeclampsia Promotes Exosomal Release of SMPD1 Causing Endothelial Dysfunction","year":2021,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; Health Sciences Centre; Sinai Health System; Sunnybrook Health Science Centre; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Ceramide; TFEB; Cell biology; Acid sphingomyelinase; Sphingomyelin phosphodiesterase; Sphingomyelin; Exocytosis; Biology; Lysosome; Autophagy; Ceramide synthase; Lipid signaling; Trophoblast; Microvesicles; Endocrinology; Immunology; Placenta; Biochemistry; Secretion; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001912536,0.0002582796,0.0002983482,0.0002602691,0.0001420758,0.0002559088,0.0001588366,0.0003532264,0.0008716854],"category_scores_gemma":[0.0001862938,0.0001354366,0.0002651089,0.0001751934,0.0002310103,0.0001961954,0.000325479,0.0004497771,0.0002153309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002994653,"about_ca_system_score_gemma":0.0001689815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00021275,"about_ca_topic_score_gemma":0.0002073316,"domain_scores_codex":[0.999876,0.000028243,0.00001714,0.0000223125,0.00002722176,0.00002909666],"domain_scores_gemma":[0.9999062,0.00001665217,0.00002937922,0.000009291019,0.000008302379,0.00003025616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005866709,0.00003408251,0.001688019,0.00007210307,0.00001164326,0.001886801,0.00004750005,0.00007916142,0.9925092,0.0002322051,0.00007060167,0.002782081],"study_design_scores_gemma":[0.00004574945,0.000357383,0.0363033,0.0000143623,0.00004168948,0.006380021,0.0001287868,0.001565035,0.9520594,0.0005149179,0.002579987,0.000009401461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912367,0.00264439,0.004820304,0.0002042379,0.00002604073,0.00002506931,0.0001994676,0.00007823115,0.0007657356],"genre_scores_gemma":[0.9967234,0.00130531,0.0009521435,0.00003541928,0.000008073231,0.00001902828,0.000117498,0.000007115841,0.0008321317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008716854,"threshold_uncertainty_score":0.002916098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009915944802585702,"score_gpt":0.2113148869633408,"score_spread":0.2013989421607551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}