{"id":"W3157406546","doi":"10.1073/pnas.2024272118","title":"Phosphorylation-dependent subfunctionalization of the calcium-dependent protein kinase CPK28","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Plant-Microbe Interactions and Immunity","field":"Agricultural and Biological Sciences","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada; National Science Foundation","keywords":"Phosphorylation; Autophosphorylation; Biology; Phosphorylation cascade; Kinase; Cell biology; Protein phosphorylation; Biochemistry; Protein kinase A; Arabidopsis; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006838493,0.00008074468,0.0001150672,0.00002264408,0.0003647141,0.00003083089,0.0005908937,0.00007175604,0.0001894026],"category_scores_gemma":[0.000473491,0.00002851509,0.0001082083,0.0008077542,0.0003140684,0.0003146093,0.0001892153,0.0001554727,0.00000172588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003875569,"about_ca_system_score_gemma":0.00003501687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009346926,"about_ca_topic_score_gemma":0.000005633752,"domain_scores_codex":[0.9984188,0.00002262218,0.0003413135,0.0001849396,0.0009217276,0.0001105731],"domain_scores_gemma":[0.9987509,0.000115627,0.0004859589,0.000008063806,0.0006179068,0.000021578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001152841,0.00009194743,0.007447923,0.00001383341,0.000009457878,4.964721e-9,0.00003636901,0.00007098995,0.9838293,0.007800085,0.0002269314,0.0004616771],"study_design_scores_gemma":[0.00005807691,0.00002353463,0.1903726,0.00007448348,0.000007586863,0.000009169066,0.0002509823,0.0001090145,0.8023975,0.006087637,0.0005597368,0.0000496128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940897,0.0001087429,8.599288e-7,0.003040322,0.00005235523,0.0001788456,0.00007648241,0.000006457657,0.002446287],"genre_scores_gemma":[0.998764,0.00001588368,0.00008321288,0.0001406797,0.00005349595,0.000009754351,0.000001660274,5.375663e-7,0.0009308033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1829247,"threshold_uncertainty_score":0.2805123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04191521813308954,"score_gpt":0.2650915097604616,"score_spread":0.2231762916273721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}