{"id":"W3157411382","doi":"10.21203/rs.3.rs-440618/v1","title":"An Open-Label Prospective Pilot Trial of Nucleus Accumbens Deep Brain Stimulation for Children with Autism Spectrum Disorder and Severe, Refractory Self-Injurious Behaviour: Study Protocol","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University Health Network; Surrey Place Centre; SickKids Foundation","funders":"","keywords":"Nucleus accumbens; Autism spectrum disorder; Deep brain stimulation; Refractory (planetary science); Autism; Open label; Stimulation; Psychology; Neuroscience; Protocol (science); Brain stimulation reward; Psychiatry; Clinical psychology; Medicine; Clinical trial; Physics; Internal medicine; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002724373,0.004542158,0.00496546,0.000659471,0.001643398,0.001440763,0.002187098,0.002728839,0.01746474],"category_scores_gemma":[0.002791399,0.001725613,0.001844291,0.0005627333,0.003014643,0.001518846,0.0009539902,0.005386777,0.004197557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001929704,"about_ca_system_score_gemma":0.005685985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003986083,"about_ca_topic_score_gemma":0.007568927,"domain_scores_codex":[0.9985231,0.0005885088,0.00009777147,0.0003307668,0.0001315571,0.0003284134],"domain_scores_gemma":[0.9981976,0.0004078481,0.0002506127,0.0002578172,0.0001695987,0.0007166222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9476022,0.03861667,0.0003954156,0.0004037276,0.000331254,0.00008395776,0.00009739271,0.0006736373,0.00258955,0.0003011375,0.001313247,0.007591911],"study_design_scores_gemma":[0.8856951,0.111421,0.0009008519,0.00002589375,0.0001222026,0.00002638688,0.00003645842,0.0002780566,0.0002739084,0.0002416116,0.000957297,0.00002123621],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.7107592,0.001378057,0.004757985,0.00106008,0.001194785,0.2680239,0.006352514,0.0004476039,0.006025943],"genre_scores_gemma":[0.581637,0.001758046,0.01097571,0.001796162,0.000774668,0.3906482,0.00289843,0.00009678545,0.009415014],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01746474,"threshold_uncertainty_score":0.05842543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08772074289695017,"score_gpt":0.4683856234999083,"score_spread":0.3806648806029581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}