{"id":"W3157441991","doi":"10.3389/ftox.2021.653386","title":"Adverse Outcome Pathway Development for Assessment of Lung Carcinogenicity by Nanoparticles","year":2021,"lang":"en","type":"article","venue":"Frontiers in Toxicology","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Health Canada; Horizon 2020 Framework Programme; Vetenskapsrådet; European Commission; Karolinska Institutet; Svenska Forskningsrådet Formas; Stiftelsen Forska Utan Djurförsök","keywords":"Adverse Outcome Pathway; Risk assessment; Risk analysis (engineering); Computer science; Lung cancer; Carcinogen; Nanotechnology; Biochemical engineering; Medicine; Computational biology; Chemistry; Pathology; Biology; Materials science; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002694192,0.00009894684,0.0003721464,0.0001015253,0.00004455737,0.000002184162,0.00005344027,0.0001337823,0.00008629236],"category_scores_gemma":[0.00009220522,0.00009314017,0.00008257705,0.0001340321,0.00006596615,0.00003153,0.00003741081,0.0001111026,0.000001475722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002535606,"about_ca_system_score_gemma":0.000528064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001283451,"about_ca_topic_score_gemma":0.00001402068,"domain_scores_codex":[0.9988804,0.00008077574,0.0004612443,0.000215672,0.0001336054,0.0002283338],"domain_scores_gemma":[0.9995091,0.0000427477,0.00009845736,0.0001509899,0.0001230312,0.00007568204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001298321,0.0004431792,0.8389959,0.0001801918,0.00009690772,0.00005670506,0.0002821343,0.00005865145,0.1443784,0.0001330916,0.01236109,0.002883865],"study_design_scores_gemma":[0.005073942,0.0002600209,0.1801603,0.00004414023,0.00007937399,0.00001783584,0.0009768957,0.004042869,0.7697199,0.00002709549,0.03937292,0.0002246659],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887438,0.0005167838,0.008576544,0.0003358438,0.0008168508,0.0003868499,0.00001803432,0.00001602573,0.0005892179],"genre_scores_gemma":[0.9662669,0.000009823699,0.03155223,0.000916559,0.00002666133,0.0000607332,0.00004036626,0.00001175683,0.001114967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6588356,"threshold_uncertainty_score":0.3798146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02867373619413855,"score_gpt":0.316277670460539,"score_spread":0.2876039342664004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}