{"id":"W3157441991","doi":"10.3389/ftox.2021.653386","title":"Adverse Outcome Pathway Development for Assessment of Lung Carcinogenicity by Nanoparticles","year":2021,"lang":"en","type":"article","venue":"Frontiers in Toxicology","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Health Canada; Horizon 2020 Framework Programme; Vetenskapsrådet; European Commission; Karolinska Institutet; Svenska Forskningsrådet Formas; Stiftelsen Forska Utan Djurförsök","keywords":"Adverse Outcome Pathway; Risk assessment; Risk analysis (engineering); Computer science; Lung cancer; Carcinogen; Nanotechnology; Biochemical engineering; Medicine; Computational biology; Chemistry; Pathology; Biology; Materials science; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00810788,0.001651319,0.0009084061,0.002439806,0.0005068178,0.001685378,0.001598679,0.001105889,0.00344691],"category_scores_gemma":[0.007155569,0.000428454,0.001793841,0.000946419,0.0009446042,0.001628423,0.002937678,0.001552713,0.001017929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001478752,"about_ca_system_score_gemma":0.003503119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001653228,"about_ca_topic_score_gemma":0.001911721,"domain_scores_codex":[0.9947386,0.001584175,0.000349061,0.0007338009,0.0023765,0.0002177353],"domain_scores_gemma":[0.9950386,0.001207332,0.00118253,0.0004327421,0.001960595,0.0001781939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001587551,0.0008449185,0.04323765,0.01290701,0.0009718139,0.0019552,0.0009167158,0.04635674,0.3745247,0.09965287,0.008636608,0.4084083],"study_design_scores_gemma":[0.0001876205,0.006012046,0.02276185,0.001946156,0.001270668,0.003214469,0.0008023599,0.09783526,0.6113751,0.08158273,0.1726403,0.0003713349],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.0538939,0.008674281,0.91014,0.001220869,0.0003112483,0.002790997,0.003881419,0.001475824,0.01761148],"genre_scores_gemma":[0.3781224,0.01898078,0.5816914,0.0008307457,0.0001502525,0.005356704,0.00628773,0.0003217711,0.008258041],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.00810788,"threshold_uncertainty_score":0.0428791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02867373619413855,"score_gpt":0.316277670460539,"score_spread":0.2876039342664004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}