{"id":"W3157459727","doi":"10.1101/2021.02.09.21250262","title":"Investigation of Autosomal Genetic Sex Differences in Parkinson’s disease","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Institute of Genetics; National Institute of Environmental Health Sciences; Medical Research Council; Michael J. Fox Foundation for Parkinson's Research; Parkinson Vereniging; Assistance publique-Hôpitaux de Paris; National Institute of Neurological Disorders and Stroke; Fondation de France; Bundesministerium für Bildung und Forschung; Parkinson's UK; Multiple System Atrophy Coalition; National Institute on Aging; American Parkinson Disease Association; Consortium canadien en neurodégénérescence associée au vieillissement; Agence Nationale de la Recherche; Wellcome Trust; McGill University; Deutsche Forschungsgemeinschaft; Helsingin ja Uudenmaan Sairaanhoitopiiri; Helsingin Yliopisto; EU Joint Programme – Neurodegenerative Disease Research; U.S. Department of Defense; Itä-Suomen Yliopisto; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Genome-wide association study; Genetic architecture; Autosome; Disease; Heritability; Biology; Etiology; Parkinson's disease; Genetic association; Genetics; Genetic variation; Biobank; Medicine; Internal medicine; Quantitative trait locus; Single-nucleotide polymorphism; Genotype; X chromosome; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003674958,0.0006698332,0.000961238,0.001301789,0.0004566261,0.0009627944,0.0006899909,0.0005648225,0.002885127],"category_scores_gemma":[0.006519537,0.0002791053,0.00319158,0.002123073,0.0003464126,0.0004429245,0.0006645974,0.0006902829,0.0001679306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002577138,"about_ca_system_score_gemma":0.0002953114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002526428,"about_ca_topic_score_gemma":0.002640151,"domain_scores_codex":[0.99751,0.001150908,0.0002139126,0.0007030219,0.000287443,0.0001347581],"domain_scores_gemma":[0.9950948,0.003104546,0.0008822093,0.0004810509,0.0002788822,0.0001585275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001495928,0.0000307424,0.951929,0.0006760936,0.02211125,0.0006657825,0.0001846843,0.0005762953,0.00273243,0.0006744806,0.0006333786,0.01829004],"study_design_scores_gemma":[0.0001432297,0.0003900597,0.9743183,0.0002121903,0.01531091,0.001311673,0.0002003901,0.001930794,0.001249748,0.001670109,0.003241455,0.00002115011],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9438642,0.04405494,0.00613617,0.0007152305,0.0002261566,0.00004127906,0.002986224,0.00005849406,0.001917377],"genre_scores_gemma":[0.995068,0.00255337,0.0009657864,0.0001704109,0.00006579198,0.00002219921,0.0007937569,0.00002050475,0.0003402614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003674958,"threshold_uncertainty_score":0.01943523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0367054211678582,"score_gpt":0.2611049528181261,"score_spread":0.2243995316502679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}