{"id":"W3157519920","doi":"10.1039/d1ob00524c","title":"An easily accessible, lower rim substituted calix[4]arene selectively binds <i>N</i>,<i>N</i>-dimethyllysine","year":2021,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Sulfonate; Methylation; Lysine; Stereochemistry; Calixarene; Arginine; Combinatorial chemistry; Molecule; Biochemistry; Amino acid; Organic chemistry; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002037752,0.0005166658,0.00048803,0.00004274876,0.0001977918,0.0001597699,0.0006522495,0.0005472086,0.001281665],"category_scores_gemma":[0.0002846115,0.0005313572,0.0004186312,0.001077788,0.0001721843,0.00001910481,0.000274646,0.0002656737,0.00004304327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000754751,"about_ca_system_score_gemma":0.0004502616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003540165,"about_ca_topic_score_gemma":0.0000202808,"domain_scores_codex":[0.9969984,0.0001083594,0.0004937254,0.001316159,0.0004335063,0.0006498627],"domain_scores_gemma":[0.9976551,0.00001643983,0.0001914248,0.001256405,0.0004411261,0.0004395268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006249121,0.0005445902,0.0008364091,0.00005781945,0.0003501002,0.0001800465,0.000009367118,0.000002713502,0.9964165,0.000004060043,0.0008506298,0.0006852923],"study_design_scores_gemma":[0.0007112153,0.00004842825,0.0002980127,0.00003306966,0.0002286022,0.0001136129,0.00003596458,0.00006195435,0.9888523,0.0000439541,0.008877852,0.0006950805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9573476,0.002950546,0.03662362,0.0003128369,0.0001115395,0.0001035289,0.00009163893,0.00009801117,0.0023607],"genre_scores_gemma":[0.9948127,0.0002756761,0.001091191,0.0005335582,0.0005278853,0.00001992652,0.001436682,0.0001057641,0.001196656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03746508,"threshold_uncertainty_score":0.9997138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0054385927468561,"score_gpt":0.2404763845815792,"score_spread":0.2350377918347231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}