{"id":"W3157533736","doi":"10.1101/gr.275263.121","title":"Purifying selection on noncoding deletions of human regulatory loci detected using their cellular pleiotropy","year":2021,"lang":"en","type":"article","venue":"Genome Research","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Science Foundation Graduate Research Fellowship Program; National Human Genome Research Institute; National Institute of Mental Health; National Institutes of Health; Genentech; U.S. National Library of Medicine; IXICO; National Institute of General Medical Sciences; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Foundation for the National Institutes of Health; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Science Foundation","keywords":"Biology; Chromatin; CTCF; Genetics; Negative selection; Enhancer; Noncoding DNA; Heterochromatin; Histone; Genome; ChIA-PET; Computational biology; Chromatin remodeling; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001200694,0.0003693515,0.0002861777,0.0005389492,0.0001933081,0.0003645802,0.0004024683,0.0002892386,0.0006857017],"category_scores_gemma":[0.002840599,0.0001865654,0.0005262593,0.0004895409,0.0004458353,0.0002623684,0.0004684517,0.0005120475,0.0001010594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002812725,"about_ca_system_score_gemma":0.0001837951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007606543,"about_ca_topic_score_gemma":0.001567881,"domain_scores_codex":[0.9993679,0.0002426515,0.00003775178,0.0002368895,0.00008425494,0.00003059793],"domain_scores_gemma":[0.9982912,0.001134877,0.0002737532,0.0001925358,0.00004736885,0.00006035478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008557309,0.0001171091,0.1567867,0.0002392519,0.0006766336,0.0009926003,0.0004154381,0.2190428,0.5695369,0.007569266,0.0002621322,0.04350549],"study_design_scores_gemma":[0.0001019022,0.0006554077,0.1850088,0.00002545503,0.0002670735,0.0008846322,0.0001387762,0.6933947,0.1064193,0.01099295,0.002026145,0.00008490569],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9507157,0.00009662241,0.04826236,0.00002479948,0.000004535873,0.00002115062,0.0003046412,0.0002273117,0.0003429586],"genre_scores_gemma":[0.9859921,0.00004885377,0.01329247,0.00001782463,0.000003454573,0.00003099705,0.0004453007,0.00004641338,0.0001226219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001200694,"threshold_uncertainty_score":0.006349921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05916128674971523,"score_gpt":0.3297413885942199,"score_spread":0.2705801018445047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}