{"id":"W3157533736","doi":"10.1101/gr.275263.121","title":"Purifying selection on noncoding deletions of human regulatory loci detected using their cellular pleiotropy","year":2021,"lang":"en","type":"article","venue":"Genome Research","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Science Foundation Graduate Research Fellowship Program; National Human Genome Research Institute; National Institute of Mental Health; National Institutes of Health; Genentech; U.S. National Library of Medicine; IXICO; National Institute of General Medical Sciences; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Foundation for the National Institutes of Health; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Science Foundation","keywords":"Biology; Chromatin; CTCF; Genetics; Negative selection; Enhancer; Noncoding DNA; Heterochromatin; Histone; Genome; ChIA-PET; Computational biology; Chromatin remodeling; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005222118,0.0001202467,0.0001470158,0.0001428795,0.0004002955,0.00003783362,0.0001890581,0.0001678349,0.00004867589],"category_scores_gemma":[0.00006163657,0.0001284425,0.00009749371,0.000336285,0.00009828317,0.000002737447,0.0001978379,0.0002578219,0.000004981623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001208769,"about_ca_system_score_gemma":0.0002697691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003154471,"about_ca_topic_score_gemma":0.00005387175,"domain_scores_codex":[0.998545,0.0002125531,0.0002383428,0.0003624636,0.0002589021,0.0003827288],"domain_scores_gemma":[0.9989792,0.0000198814,0.00006983782,0.0004050867,0.0004460082,0.00007998513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001523931,0.00005955834,0.0004508664,0.00004702498,0.00004765833,0.000004503004,0.00006997032,0.001587352,0.997153,0.0002470423,0.00002357619,0.0002942069],"study_design_scores_gemma":[0.0002601148,0.0002428547,0.00253805,0.00002210618,0.000007992148,0.00001489239,0.000274913,0.003021867,0.992172,0.0002432259,0.001057167,0.0001448272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960153,0.0006390996,0.002565207,0.00002552813,0.00003987782,0.0001425491,0.00001868961,0.000008726814,0.0005450973],"genre_scores_gemma":[0.9975264,0.0001132035,0.001616338,0.00001000926,0.0002230933,0.000008848172,0.0001692245,0.00003550285,0.0002973751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004981012,"threshold_uncertainty_score":0.5237734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05916128674971523,"score_gpt":0.3297413885942199,"score_spread":0.2705801018445047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}