{"id":"W3157537380","doi":"10.1126/sciadv.abf3114","title":"A parental transcriptional response to microsporidia infection induces inherited immunity in offspring","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Courant Forschungszentrum Geobiologie, Georg-August-Universität Göttingen; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Alfred P. Sloan Foundation","keywords":"Biology; Immunity; Offspring; Immune system; Caenorhabditis elegans; Acquired immune system; Microsporidia; Intracellular parasite; Maternal effect; Genetics; Immunology; Microbiology; Gene; Spore","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001536879,0.0002482202,0.0001337047,0.0001366977,0.0001022024,0.000198419,0.0001461053,0.0001838286,0.001328696],"category_scores_gemma":[0.0001481049,0.0001020008,0.0001424511,0.00005702101,0.0001757151,0.0001014049,0.0002895543,0.0005888403,0.0002779398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002073271,"about_ca_system_score_gemma":0.000142015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001916094,"about_ca_topic_score_gemma":0.0005246919,"domain_scores_codex":[0.999887,0.00001692405,0.000008190884,0.00003571304,0.00003116329,0.00002098573],"domain_scores_gemma":[0.9998038,0.0000424153,0.00004730934,0.00003308733,0.00001902598,0.00005423907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002176424,0.000004940695,0.0004305895,0.000006094756,0.00000187577,0.00003128571,0.000009754841,0.000009505427,0.9989969,0.00005391105,0.00001167582,0.000421619],"study_design_scores_gemma":[0.000009447102,0.0002169997,0.03250324,0.000005878378,0.00002088387,0.0003798854,0.00005037362,0.0005289237,0.9648994,0.00006021911,0.001317847,0.000006725776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952056,0.0003213096,0.003023077,0.0000627363,0.00001729339,0.000006747438,0.0001934898,0.00008147395,0.001088112],"genre_scores_gemma":[0.9968615,0.000153193,0.00092436,0.00003764335,0.000006324991,0.00001061697,0.0002068647,0.00002339423,0.00177619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001328696,"threshold_uncertainty_score":0.004444957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01297788112361587,"score_gpt":0.2775091810584706,"score_spread":0.2645312999348547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}