{"id":"W3157537380","doi":"10.1126/sciadv.abf3114","title":"A parental transcriptional response to microsporidia infection induces inherited immunity in offspring","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Courant Forschungszentrum Geobiologie, Georg-August-Universität Göttingen; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Alfred P. Sloan Foundation","keywords":"Biology; Immunity; Offspring; Immune system; Caenorhabditis elegans; Acquired immune system; Microsporidia; Intracellular parasite; Maternal effect; Genetics; Immunology; Microbiology; Gene; Spore","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005036696,0.00009765496,0.0000882756,0.00009698972,0.0001679459,0.0000549127,0.0001892897,0.00004737093,0.00001349446],"category_scores_gemma":[0.0002122542,0.0001058833,0.0000336828,0.0005038092,0.0002076543,0.00002843069,0.00009496274,0.00009082804,0.000006935185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003991732,"about_ca_system_score_gemma":0.0002715123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007645778,"about_ca_topic_score_gemma":0.0006363484,"domain_scores_codex":[0.9989753,0.00007070998,0.0001543883,0.0003630178,0.0001879161,0.0002486399],"domain_scores_gemma":[0.9995474,0.000008862015,0.00003382815,0.0002136167,0.0001150763,0.00008122191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007974793,0.00005385713,0.02667911,0.000005170928,0.000001988533,0.000003223692,0.0005833011,0.0008713227,0.9697323,0.000008368506,0.000004398234,0.001977209],"study_design_scores_gemma":[0.0001538087,0.00007426219,0.3391785,0.00001144102,0.000001531128,0.00001042595,0.0002484343,0.000008563394,0.6554145,0.00005694214,0.004739156,0.0001024577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997511,0.0008884784,0.0008623236,0.0001918772,0.0003804293,0.00008236791,0.000007729039,0.000009802364,0.00006604145],"genre_scores_gemma":[0.9973281,0.0001328576,0.002126974,0.0002239658,0.0000543804,0.00001024812,0.00001435515,0.000006775763,0.0001023395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3143178,"threshold_uncertainty_score":0.4317796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01297788112361587,"score_gpt":0.2775091810584706,"score_spread":0.2645312999348547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}