{"id":"W3157567544","doi":"10.1002/ana.26094","title":"Genomewide Association Studies of <scp> <i>LRRK2</i> </scp> Modifiers of Parkinson's Disease","year":2021,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; Toronto Western Hospital; Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; National Institute on Aging; Canadian Institutes of Health Research; National Center for Advancing Translational Sciences; Morsani College of Medicine; School of Medicine, Stanford University; National Institutes of Health; Sorbonne Université; St. Olavs Hospital Universitetssykehuset i Trondheim; Universität zu Köln; Universitat de Barcelona; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Centre National de la Recherche Scientifique; Tel Aviv University; University of Washington; Johns Hopkins University; Eberhard Karls Universität Tübingen; Institut National de la Santé et de la Recherche Médicale; Deutsche Forschungsgemeinschaft; Google; University College Dublin; University of Reading; Oracle; Consortium canadien en neurodégénérescence associée au vieillissement; Albertson Parkinson's Research Foundation; Agence Nationale de la Recherche; Sol Goldman Charitable Trust; Clinical and Translational Science Institute, University of Florida; Parkinson's Foundation; University of Pennsylvania; Little Family Foundation; Michael J. Fox Foundation for Parkinson's Research; University of Miami; Deutsches Zentrum für Neurodegenerative Erkrankungen; McKnight Foundation; Sagol School of Neuroscience, Tel Aviv University; University of California, San Francisco; Brookdale Foundation; Vagelos College of Physicians and Surgeons, Columbia University; Leonard M. Miller School of Medicine; University of Toronto; U.S. Department of Veterans Affairs; University of South Florida; U.S. Department of Defense","keywords":"Penetrance; LRRK2; Genetics; Disease; Parkinson's disease; Allele; Mutation; Biology; Oncology; Medicine; Internal medicine; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001455457,0.0006073493,0.0005784588,0.0008797697,0.0002883127,0.0005090017,0.0004630935,0.0005935152,0.002071781],"category_scores_gemma":[0.003275147,0.0001503736,0.0008467254,0.001226757,0.0003982896,0.0001664825,0.0004549148,0.0004600923,0.0001849656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001940591,"about_ca_system_score_gemma":0.0003006766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003332672,"about_ca_topic_score_gemma":0.003466035,"domain_scores_codex":[0.9989989,0.0003379092,0.00008309339,0.0003696065,0.0001240512,0.00008634654],"domain_scores_gemma":[0.9975421,0.0009980797,0.001006317,0.0001484945,0.000155701,0.0001493456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001314274,0.00007326436,0.9745725,0.0001259616,0.002727639,0.001001898,0.0001210581,0.0006098496,0.01219164,0.0001265916,0.0002640264,0.006871168],"study_design_scores_gemma":[0.00005290559,0.0001590553,0.9967661,0.00001541809,0.0008481063,0.0005593758,0.00002972853,0.0003648357,0.0007915755,0.0001033576,0.0003035785,0.000005947249],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958987,0.002041988,0.0008360186,0.0001700771,0.00001465066,0.00001364561,0.0005228895,0.00003492394,0.0004671895],"genre_scores_gemma":[0.9986354,0.0003508522,0.0004648875,0.0000411511,0.00002393531,0.000008612604,0.0003276948,0.000007008083,0.0001405251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003332672,"threshold_uncertainty_score":0.007697284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07117441980185504,"score_gpt":0.3318073351992157,"score_spread":0.2606329153973607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}