{"id":"W3157575440","doi":"10.1016/j.euros.2021.04.005","title":"Estetrol Cotreatment of Androgen Deprivation Therapy in Infiltrating or Metastatic, Castration-sensitive Prostate Cancer: A Randomized, Double-blind, Phase II Trial (PCombi)","year":2021,"lang":"en","type":"article","venue":"European Urology Open Science","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Pantharei Bioscience","keywords":"Medicine; Prostate cancer; Internal medicine; Androgen deprivation therapy; Testosterone (patch); Endocrinology; Placebo; N-terminal telopeptide; Goserelin; Urology; Population; Luteinizing hormone; Cancer; Osteocalcin; Hormone; Alkaline phosphatase; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001091201,0.00118134,0.001554545,0.0003544901,0.0002385008,0.0006390812,0.0005838684,0.0008289203,0.003068696],"category_scores_gemma":[0.0008064213,0.0004061654,0.0008041192,0.0003122614,0.0007341337,0.0004279306,0.0002449217,0.00160911,0.0003453404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004040464,"about_ca_system_score_gemma":0.0008310387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000752636,"about_ca_topic_score_gemma":0.001758519,"domain_scores_codex":[0.9997036,0.0001681914,0.00001687534,0.00004153901,0.0000282633,0.00004153635],"domain_scores_gemma":[0.9996126,0.0001036277,0.00009303827,0.00003248229,0.00002232761,0.0001359045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9384578,0.01203384,0.001275493,0.001152932,0.0006697111,0.00005883846,0.00007112687,0.0003525594,0.0134587,0.0001370787,0.0008646747,0.03146726],"study_design_scores_gemma":[0.8758532,0.1190284,0.00279594,0.0000221965,0.0002531316,0.00004041887,0.00001232387,0.0003554855,0.0009503124,0.00004096397,0.000638566,0.00000912142],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935801,0.002806333,0.0002735097,0.0002010496,0.00014325,0.001789537,0.0003295704,0.00006886581,0.0008077851],"genre_scores_gemma":[0.9902583,0.002561776,0.0009600231,0.0004412204,0.000267459,0.002870688,0.0007541635,0.00001498752,0.001871331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003068696,"threshold_uncertainty_score":0.01026577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1112705200706817,"score_gpt":0.4198355365680645,"score_spread":0.3085650164973828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}