{"id":"W3157575440","doi":"10.1016/j.euros.2021.04.005","title":"Estetrol Cotreatment of Androgen Deprivation Therapy in Infiltrating or Metastatic, Castration-sensitive Prostate Cancer: A Randomized, Double-blind, Phase II Trial (PCombi)","year":2021,"lang":"en","type":"article","venue":"European Urology Open Science","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Pantharei Bioscience","keywords":"Medicine; Prostate cancer; Internal medicine; Androgen deprivation therapy; Testosterone (patch); Endocrinology; Placebo; N-terminal telopeptide; Goserelin; Urology; Population; Luteinizing hormone; Cancer; Osteocalcin; Hormone; Alkaline phosphatase; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002787617,0.0001906951,0.0006941559,0.0002367173,0.0002781588,0.0001059641,0.0003311966,0.00002663067,0.0001186136],"category_scores_gemma":[0.0004237464,0.0001259212,0.00007705317,0.001095142,0.0008423693,0.0003897497,0.0002787469,0.000193478,0.000007821155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000124548,"about_ca_system_score_gemma":0.002426833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002909148,"about_ca_topic_score_gemma":0.0001893709,"domain_scores_codex":[0.99717,0.0007620522,0.000629444,0.00060265,0.0004406931,0.0003951992],"domain_scores_gemma":[0.9984315,0.0003066879,0.0002791724,0.000359578,0.000475501,0.000147569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9500305,0.001650481,0.001495358,0.00001176996,0.0002035431,0.001083832,0.003662425,0.0001111372,0.0203643,0.0001719668,0.0000223578,0.02119235],"study_design_scores_gemma":[0.9170718,0.005851371,0.0004362639,0.00004532529,0.000105514,0.0001165317,0.0004173666,0.0005784971,0.07504282,0.00003587713,0.0001776259,0.0001209721],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880359,0.0004981555,0.0000565864,0.00209093,0.0001494513,0.005167521,0.00002151539,0.00001454067,0.003965395],"genre_scores_gemma":[0.9965481,0.0008383996,0.0009100889,0.0003278683,0.0000416569,0.0003248987,0.00006590032,0.00001864794,0.000924512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05467853,"threshold_uncertainty_score":0.5134919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1112705200706817,"score_gpt":0.4198355365680645,"score_spread":0.3085650164973828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}