{"id":"W3157584831","doi":"10.1002/cam4.3910","title":"Trametinib therapy for children with neurofibromatosis type 1 and life‐threatening plexiform neurofibroma or treatment‐refractory low‐grade glioma","year":2021,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Trametinib; Neurofibromatosis; Refractory (planetary science); Adverse effect; Clinical trial; Internal medicine; Surgery; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008871671,0.0005273318,0.001039715,0.0001876154,0.0002159745,0.00004659069,0.0001074959,0.0001361855,0.0004283531],"category_scores_gemma":[0.000242113,0.0003117674,0.0001162051,0.0007946558,0.0003000653,0.0001517707,0.00003235085,0.0001815966,0.000004126127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007017404,"about_ca_system_score_gemma":0.0006740562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001405038,"about_ca_topic_score_gemma":0.00002247308,"domain_scores_codex":[0.9976406,0.00007298121,0.0005009802,0.0008445118,0.0003937443,0.0005472556],"domain_scores_gemma":[0.9980054,0.0003468171,0.0002030057,0.0005688118,0.0002907657,0.0005851488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02395504,0.001854206,0.2991191,0.001090025,0.002726248,0.003563071,0.002130518,0.00001184471,0.5617878,0.0002574239,0.01818204,0.08532263],"study_design_scores_gemma":[0.04827258,0.04221407,0.6483874,0.002019257,0.001724255,0.00923472,0.0007886706,0.0001391705,0.2216475,0.00005394872,0.0244147,0.00110369],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980325,0.0132004,0.00001879304,0.004519709,0.0003388068,0.001157238,0.00008649266,0.000176703,0.0001768728],"genre_scores_gemma":[0.9886651,0.006018271,0.0006514419,0.002399429,0.0009044037,0.000250362,0.0002069471,0.0001584352,0.0007455781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3492683,"threshold_uncertainty_score":0.9999334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05389733000737129,"score_gpt":0.3184927133840226,"score_spread":0.2645953833766513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}