{"id":"W3157600695","doi":"10.1016/j.molcel.2021.04.017","title":"ecDNA party bus: Bringing the enhancer to you","year":2021,"lang":"en","type":"letter","venue":"Molecular Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Banting Research Foundation","keywords":"Extrachromosomal DNA; Biology; Enhancer; Chromatin; DNA; Genetics; Gene; Transcription factor; Molecular biology; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001389504,0.0003949958,0.0002716666,0.00004266737,0.0001165618,0.0001332229,0.0006492058,0.0006079674,0.00008884406],"category_scores_gemma":[0.00002920255,0.0003444467,0.000308202,0.0001169279,0.00004696763,0.00000107608,0.0004992625,0.0006365945,0.00009027765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003829817,"about_ca_system_score_gemma":0.0001493569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001991993,"about_ca_topic_score_gemma":0.00001384514,"domain_scores_codex":[0.9980628,0.0001032328,0.0002833176,0.0007478669,0.0002586941,0.0005440353],"domain_scores_gemma":[0.9984619,0.00001034149,0.000127147,0.001219622,0.0001023154,0.00007865911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003400886,0.00001554123,0.000005342047,0.00007505583,0.00007666052,0.0003795466,0.00004508477,0.0003246338,0.4891066,0.000003339749,0.5095479,0.0004168562],"study_design_scores_gemma":[0.0001158889,0.00004578992,0.000005740728,0.00002576824,0.00005092221,0.00001956018,0.00002201563,0.00008601074,0.2391605,0.00002235577,0.7600776,0.0003678851],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.5243503,0.01452052,0.02776596,0.3817973,0.002765276,0.001728762,0.0003285621,0.00008459514,0.04665864],"genre_scores_gemma":[0.1048102,0.0004454971,0.002904828,0.8519131,0.00362501,0.0001526295,0.002962494,0.0003258152,0.03286045],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.4701158,"threshold_uncertainty_score":0.9999008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004921206274725312,"score_gpt":0.1976036287272999,"score_spread":0.1926824224525746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}