{"id":"W3157600695","doi":"10.1016/j.molcel.2021.04.017","title":"ecDNA party bus: Bringing the enhancer to you","year":2021,"lang":"en","type":"letter","venue":"Molecular Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Banting Research Foundation","keywords":"Extrachromosomal DNA; Biology; Enhancer; Chromatin; DNA; Genetics; Gene; Transcription factor; Molecular biology; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003826204,0.0008950198,0.001249357,0.0005191252,0.006693235,0.006351618,0.001974364,0.07359024,0.01741907],"category_scores_gemma":[0.01499492,0.0009561331,0.001337499,0.0003813101,0.003853128,0.006083741,0.003514593,0.06128087,0.01081981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003937419,"about_ca_system_score_gemma":0.004879917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007910905,"about_ca_topic_score_gemma":0.01818086,"domain_scores_codex":[0.9972831,0.0005190606,0.0001723466,0.0003718347,0.000991223,0.000662381],"domain_scores_gemma":[0.9949273,0.002410158,0.0002143454,0.000254739,0.0006551887,0.001538316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007114626,0.00002731207,0.0001696616,0.00002069791,0.00001134306,0.0006370316,0.00006434882,0.00003185307,0.0002112264,0.004597944,0.9877908,0.006366678],"study_design_scores_gemma":[0.0001085102,0.0000506383,0.0004275228,0.00007267956,0.00001765135,0.000483463,0.0002735007,0.0001651209,0.0003222828,0.01337217,0.9846675,0.00003899256],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0003863453,0.00241956,0.0002707542,0.9554378,0.03447709,0.00001782049,0.00005482693,0.00005952678,0.006876301],"genre_scores_gemma":[0.002577581,0.0007196673,0.000243682,0.9385753,0.01888711,0.00003360377,0.00002733531,0.00003528839,0.03890051],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.07359024,"threshold_uncertainty_score":0.0582726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004921206274725312,"score_gpt":0.1976036287272999,"score_spread":0.1926824224525746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}