{"id":"W3157649921","doi":"10.1016/j.steroids.2021.108856","title":"Synthesis of 16β-derivatives of 3-(2-bromoethyl)-estra-1,3,5(10)-trien-17β-ol as inhibitors of 17β-HSD1 and/or steroid sulfatase for the treatment of estrogen-dependent diseases","year":2021,"lang":"en","type":"article","venue":"Steroids","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Mitacs","keywords":"Steroid sulfatase; Steroid; Estrogen; Hydroxysteroid dehydrogenase; Chemistry; Enzyme; IC50; Stereochemistry; Estrogen receptor; Estrogen receptor alpha; Side chain; Pharmacology; Dehydrogenase; Biochemistry; Internal medicine; Endocrinology; Biology; Hormone; In vitro; Cancer; Medicine; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003348214,0.0006376766,0.0005218116,0.0004540819,0.0001985385,0.0002073498,0.0005655883,0.0004466076,0.005288609],"category_scores_gemma":[0.0002038473,0.0003099296,0.0004786784,0.0003823559,0.0001986398,0.0003472483,0.0003014196,0.0005216112,0.001784041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002613049,"about_ca_system_score_gemma":0.0005805821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005798966,"about_ca_topic_score_gemma":0.0009307758,"domain_scores_codex":[0.9998469,0.0000251298,0.00001754221,0.00002355579,0.0000271648,0.00005968513],"domain_scores_gemma":[0.9998533,0.00001620134,0.00003057743,0.00001741748,0.00002935016,0.00005317254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005796779,0.0001704714,0.0002148755,0.0003925064,0.00004955033,0.0006618173,0.0001127511,0.001159253,0.9760694,0.00168284,0.0004121662,0.0184947],"study_design_scores_gemma":[0.0002288152,0.002390205,0.001967433,0.00005122765,0.00009885844,0.0008013336,0.00004738185,0.0005847043,0.9427943,0.0003912874,0.05060061,0.00004387758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8688038,0.04587724,0.03981031,0.0008549104,0.001001377,0.001003308,0.004216724,0.0004722475,0.03796008],"genre_scores_gemma":[0.931991,0.02116234,0.01521235,0.0003356894,0.0001069703,0.0003288222,0.002168497,0.00009749702,0.02859688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005288609,"threshold_uncertainty_score":0.01769215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009852386390717493,"score_gpt":0.2624779531682387,"score_spread":0.2526255667775212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}