{"id":"W3157649921","doi":"10.1016/j.steroids.2021.108856","title":"Synthesis of 16β-derivatives of 3-(2-bromoethyl)-estra-1,3,5(10)-trien-17β-ol as inhibitors of 17β-HSD1 and/or steroid sulfatase for the treatment of estrogen-dependent diseases","year":2021,"lang":"en","type":"article","venue":"Steroids","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Mitacs","keywords":"Steroid sulfatase; Steroid; Estrogen; Hydroxysteroid dehydrogenase; Chemistry; Enzyme; IC50; Stereochemistry; Estrogen receptor; Estrogen receptor alpha; Side chain; Pharmacology; Dehydrogenase; Biochemistry; Internal medicine; Endocrinology; Biology; Hormone; In vitro; Cancer; Medicine; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001029632,0.0002378281,0.0004629742,0.00005158317,0.00005108652,0.000008186234,0.0001600881,0.0001684258,0.00002525149],"category_scores_gemma":[0.0002320997,0.000156166,0.0002736043,0.0001162287,0.0003483721,0.000007665553,0.00008535587,0.00004367157,6.328385e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001334871,"about_ca_system_score_gemma":0.0002091959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003934517,"about_ca_topic_score_gemma":0.00001218389,"domain_scores_codex":[0.9986331,0.000130801,0.0005018954,0.0003288549,0.0001944321,0.0002108971],"domain_scores_gemma":[0.9985956,0.0003121813,0.0003297993,0.0004887791,0.0001792025,0.00009443727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001495384,0.000950455,0.003259237,0.0003578862,0.0008524801,0.00001162856,0.0003463623,0.00002543301,0.9834847,0.00008283184,0.0001074397,0.009026112],"study_design_scores_gemma":[0.001494364,0.003633207,0.001103443,0.0001127134,0.0003818596,0.00001659544,0.0008978719,0.00001295765,0.991656,0.00003586911,0.0005153268,0.0001397722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844185,0.0138774,0.00007878995,0.00005871579,0.0001041433,0.0005025815,0.0008973448,0.000004881928,0.00005766432],"genre_scores_gemma":[0.9960608,0.003074455,0.0002497045,0.000009085499,0.00006653574,0.00007905789,0.0001297978,0.00002731752,0.0003032355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01164233,"threshold_uncertainty_score":0.6368265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009852386390717493,"score_gpt":0.2624779531682387,"score_spread":0.2526255667775212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}