{"id":"W3157674268","doi":"10.3389/fnmol.2021.664912","title":"Environmental Enrichment Induces Epigenomic and Genome Organization Changes Relevant for Cognition","year":2021,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; National Institute on Aging; Agencia Estatal de Investigación; Social Sciences and Humanities Research Council of Canada; National Institute of General Medical Sciences; Generalitat de Catalunya; Ministerio de Ciencia e Innovación; Eberhard Karls Universität Tübingen; European Commission; Centres de Recerca de Catalunya; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; Ministerio de Economía y Competitividad; National Science Foundation","keywords":"Epigenome; Epigenomics; Chromatin; CTCF; Biology; Genome; Enhancer; Transcription factor; Genetics; Neuroscience; Computational biology; Histone; Genomic organization; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008218379,0.0002242038,0.0001923327,0.000244384,0.00009149531,0.0002168943,0.0001262373,0.0002066838,0.00119254],"category_scores_gemma":[0.0001133915,0.0001538681,0.0001811341,0.0001279551,0.0002475166,0.0001529097,0.0002875682,0.0003565515,0.0001225044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001648181,"about_ca_system_score_gemma":0.0001316029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003779743,"about_ca_topic_score_gemma":0.001283373,"domain_scores_codex":[0.9999181,0.000008153503,0.000003407834,0.00003107727,0.00001564421,0.0000236185],"domain_scores_gemma":[0.9998707,0.00001967782,0.00004523683,0.0000167704,0.00001343988,0.00003415893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006834539,0.00000619707,0.001376515,0.000009532493,0.000005844316,0.00003013506,0.00001321238,0.00003716696,0.9973031,0.00005909957,0.00001387728,0.001076974],"study_design_scores_gemma":[0.00000920125,0.0002971896,0.336732,0.000009090965,0.00003870802,0.0004623923,0.000111545,0.001002225,0.6590105,0.0003343352,0.001979524,0.0000131912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940239,0.0004676784,0.004181894,0.00003864533,0.000008976328,0.000008204661,0.0003835818,0.00007456773,0.0008126745],"genre_scores_gemma":[0.9953842,0.0002952025,0.002530106,0.00005222215,0.000005475296,0.00002282059,0.0004457654,0.00002911442,0.001235159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00119254,"threshold_uncertainty_score":0.003989458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004683716084208436,"score_gpt":0.1935216621005597,"score_spread":0.1888379460163513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}