{"id":"W3157674268","doi":"10.3389/fnmol.2021.664912","title":"Environmental Enrichment Induces Epigenomic and Genome Organization Changes Relevant for Cognition","year":2021,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; National Institute on Aging; Agencia Estatal de Investigación; Social Sciences and Humanities Research Council of Canada; National Institute of General Medical Sciences; Generalitat de Catalunya; Ministerio de Ciencia e Innovación; Eberhard Karls Universität Tübingen; European Commission; Centres de Recerca de Catalunya; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; Ministerio de Economía y Competitividad; National Science Foundation","keywords":"Epigenome; Epigenomics; Chromatin; CTCF; Biology; Genome; Enhancer; Transcription factor; Genetics; Neuroscience; Computational biology; Histone; Genomic organization; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000088948,0.0001050664,0.00009233927,0.0000433591,0.00008406745,0.00003846979,0.0001106113,0.00007250941,0.000001669824],"category_scores_gemma":[0.00006078754,0.0001218225,0.00001650629,0.00009859153,0.00007686248,0.000004249021,0.0001170139,0.00004702539,4.266743e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002591278,"about_ca_system_score_gemma":0.00004475228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.223123e-7,"about_ca_topic_score_gemma":0.000003294708,"domain_scores_codex":[0.9991599,0.00003259646,0.0001158108,0.0004132357,0.00009198007,0.0001864643],"domain_scores_gemma":[0.9997171,0.000002743733,0.00005478286,0.0001567763,0.00001917172,0.00004939704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005362474,0.00003569833,0.001253642,0.00001010239,0.000003467555,0.000009734887,0.00004009105,0.000196155,0.9976785,0.00002001892,0.00002911652,0.0007181622],"study_design_scores_gemma":[0.0007479279,0.0002740362,0.03290566,0.000008261515,0.00002652297,0.00005761136,0.0003596581,0.001835413,0.9565271,0.0004148289,0.006485123,0.0003578278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9414594,0.0009280239,0.05692511,0.0001322282,0.0002791264,0.0002010079,0.00005382078,0.000004247548,0.00001705939],"genre_scores_gemma":[0.9893442,0.001289462,0.008376158,0.0006079116,0.00002621309,0.00001858095,0.000263507,0.0000198083,0.00005412518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04854896,"threshold_uncertainty_score":0.4967778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004683716084208436,"score_gpt":0.1935216621005597,"score_spread":0.1888379460163513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}