{"id":"W3157693651","doi":"10.1016/j.bbalip.2021.158954","title":"Synthesis and molecular targets of N-13-hydroxy-octadienoyl-ethanolamine, a novel endogenous bioactive 15-lipoxygenase-derived metabolite of N-linoleoyl-ethanolamine found in the skin and saliva","year":2021,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut Universitaire de Cardiologie et de Pneumologie de Québec; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Arachidonic acid; Ethanolamine; Monoacylglycerol lipase; Lipoxygenase; Chemistry; Anandamide; Biochemistry; Endocannabinoid system; Linoleic acid; Biosynthesis; Metabolite; Stereochemistry; Fatty acid; Enzyme; Agonist; Receptor; Cannabinoid receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001405274,0.0003194246,0.0002394667,0.0002260556,0.00026024,0.0004458774,0.0002024201,0.0003481632,0.001966895],"category_scores_gemma":[0.0001223505,0.0002136452,0.0004161193,0.00008690212,0.0002778317,0.0004039476,0.0002165249,0.0004123295,0.0006562205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005048655,"about_ca_system_score_gemma":0.000388278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001110743,"about_ca_topic_score_gemma":0.001337369,"domain_scores_codex":[0.9999125,0.0000135115,0.00000530155,0.00002180175,0.00001311246,0.00003379208],"domain_scores_gemma":[0.9998962,0.00001763282,0.00002120628,0.00001045953,0.00002436711,0.00003019809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000284062,0.00002170019,0.0002272212,0.00003533252,0.00000685883,0.0001495432,0.00002908853,0.00003133872,0.9975625,0.0003605096,0.00001914574,0.001272587],"study_design_scores_gemma":[0.000022566,0.0002608719,0.007261672,0.000008856817,0.00002961886,0.0004211994,0.0001435297,0.0003371453,0.9893154,0.0001724974,0.002020888,0.000005809329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801656,0.009996772,0.005088879,0.0003200198,0.00008135293,0.000079887,0.0004938419,0.00004011152,0.003733522],"genre_scores_gemma":[0.9898499,0.002350682,0.001736299,0.00006203312,0.00002263138,0.00003209495,0.000443699,0.00001304325,0.005489587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001966895,"threshold_uncertainty_score":0.006579936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01432064087381619,"score_gpt":0.254218531581865,"score_spread":0.2398978907080488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}