{"id":"W3157715170","doi":"10.1016/s0735-1097(21)03141-7","title":"EPIGENETIC BET READER INHIBITOR APABETALONE (RVX-208) COUNTERS PROINFLAMMATORY AORTIC GENE EXPRESSION IN A DIET INDUCED OBESITY MOUSE MODEL","year":2021,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Medicine; Dyslipidemia; Insulin resistance; Proinflammatory cytokine; Obesity; Type 2 diabetes; Inflammation; Internal medicine; Diabetes mellitus; Endocrinology; Epigenetics; Blood pressure; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000238496,0.000638042,0.0004403453,0.0005700057,0.0002720882,0.0004501325,0.0003094368,0.0005248665,0.002930802],"category_scores_gemma":[0.0001307189,0.0003518676,0.0004414315,0.0002921887,0.0005043167,0.0003077897,0.0002324491,0.001965516,0.0006041333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002562594,"about_ca_system_score_gemma":0.0004626402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006185627,"about_ca_topic_score_gemma":0.001692984,"domain_scores_codex":[0.9996872,0.00003638272,0.00002038536,0.00007353172,0.00008150637,0.0001009707],"domain_scores_gemma":[0.9997647,0.00002051461,0.00007620779,0.00002373621,0.00001906676,0.00009575668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001821521,0.0002712529,0.0003494546,0.00006001064,0.00001791709,0.00006356808,0.00001789721,0.00009362401,0.9946724,0.0001920502,0.0002094457,0.002230966],"study_design_scores_gemma":[0.0002784536,0.001907203,0.005221309,0.00001928722,0.0001189507,0.0001581948,0.0001175165,0.0009807578,0.9879088,0.0001446574,0.003130454,0.00001446407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906964,0.001490247,0.003543285,0.0005258734,0.0003621995,0.00003439666,0.001118015,0.0002900549,0.001939407],"genre_scores_gemma":[0.9837046,0.002036261,0.003089207,0.000276892,0.00007187676,0.0001341166,0.001001354,0.00008304686,0.009602597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002930802,"threshold_uncertainty_score":0.009804487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01737346575502598,"score_gpt":0.265904167620873,"score_spread":0.248530701865847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}