{"id":"W3157735780","doi":"10.1016/j.sbi.2021.03.008","title":"Structural biology of endogenous membrane protein assemblies in native nanodiscs","year":2021,"lang":"en","type":"review","venue":"Current Opinion in Structural Biology","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates","keywords":"Nanodisc; Surface plasmon resonance; Structural biology; Biophysics; Transmembrane protein; Membrane protein; Chemistry; Membrane; Lipid bilayer; Electron paramagnetic resonance spectroscopy; Cryo-electron microscopy; Electron paramagnetic resonance; Nanotechnology; Materials science; Biochemistry; Biology; Nuclear magnetic resonance; Nanoparticle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002488759,0.0009209092,0.002674433,0.0005287061,0.0000683026,0.00002157012,0.0007963413,0.001250947,0.00009892892],"category_scores_gemma":[0.0002696967,0.0006987001,0.0006140596,0.0006328082,0.0004807459,0.00001271029,0.0005373998,0.0008568293,0.000003155373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001070291,"about_ca_system_score_gemma":0.0006684168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009049604,"about_ca_topic_score_gemma":0.00005502023,"domain_scores_codex":[0.995163,0.0009835577,0.001611805,0.001306716,0.0001540488,0.0007809276],"domain_scores_gemma":[0.9980497,0.00008849692,0.0008674427,0.0007013142,0.0001809531,0.0001120427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009689094,0.00007173049,0.001547099,0.0136478,0.000261537,0.000007478204,0.0001748653,0.000005324628,0.1525098,0.003432039,0.00004587606,0.8281995],"study_design_scores_gemma":[0.002489235,0.0009105575,0.0002816229,0.00873075,0.0002363473,0.0004776738,0.0001319162,0.000005217419,0.05199471,0.0004020867,0.9320921,0.002247808],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07035435,0.9212582,0.000003252823,0.0000102034,0.006093535,0.001409518,0.0007828079,0.00001483455,0.00007326766],"genre_scores_gemma":[0.06582808,0.9233341,0.0001397262,0.000006656518,0.001061378,0.0002541661,0.009290453,0.00006494428,0.00002053991],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9320462,"threshold_uncertainty_score":0.9995464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09135945309191575,"score_gpt":0.3895347614063356,"score_spread":0.2981753083144199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}