{"id":"W3157735780","doi":"10.1016/j.sbi.2021.03.008","title":"Structural biology of endogenous membrane protein assemblies in native nanodiscs","year":2021,"lang":"en","type":"review","venue":"Current Opinion in Structural Biology","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates","keywords":"Nanodisc; Surface plasmon resonance; Structural biology; Biophysics; Transmembrane protein; Membrane protein; Chemistry; Membrane; Lipid bilayer; Electron paramagnetic resonance spectroscopy; Cryo-electron microscopy; Electron paramagnetic resonance; Nanotechnology; Materials science; Biochemistry; Biology; Nuclear magnetic resonance; Nanoparticle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003899855,0.0007492626,0.000909406,0.001162263,0.0001723694,0.0008838089,0.0007254269,0.0009577861,0.001459238],"category_scores_gemma":[0.0003544679,0.0002242551,0.0002293722,0.001282776,0.0004275672,0.001347214,0.0005981791,0.00124423,0.002487839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005888276,"about_ca_system_score_gemma":0.0006466577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005415711,"about_ca_topic_score_gemma":0.0006545952,"domain_scores_codex":[0.9998957,0.00001414749,0.00001121944,0.00002321734,0.00004343511,0.00001233925],"domain_scores_gemma":[0.9998909,0.00004053041,0.00001785049,0.000005172276,0.00003032656,0.000015263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006415979,0.00006439469,0.0001005383,0.01894398,0.0000501295,0.0002641635,0.00006828499,0.0007461927,0.01411399,0.01124907,0.0341481,0.920187],"study_design_scores_gemma":[0.000008009135,0.00005566651,0.0003954463,0.001620177,0.0000376643,0.0007299717,0.00003049904,0.0001183102,0.002576929,0.002055213,0.9923537,0.00001840946],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002199586,0.9977311,0.0003436421,0.0002691195,0.0002146519,0.000005188414,0.00002912454,0.00001529934,0.001171856],"genre_scores_gemma":[0.0009527971,0.9974612,0.0002886775,0.0002060762,0.0001357633,0.000008005913,0.00005508996,0.000002838111,0.0008895425],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001459238,"threshold_uncertainty_score":0.00488162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09135945309191575,"score_gpt":0.3895347614063356,"score_spread":0.2981753083144199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}