{"id":"W3157743342","doi":"10.1101/2021.04.29.442010","title":"The natural stilbenoid (–)-hopeaphenol inhibits cellular entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7 and B.1.351 variants","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Medical Research Council; Simon Fraser University; Australian Research Council; Canadian Institutes of Health Research; Griffith University","keywords":"IC50; Viral entry; Cytopathic effect; Vero cell; Cytotoxicity; In vitro; Small molecule; Chemistry; Receptor; Virology; Biology; Binding site; Viral replication; Virus; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006115663,0.0002141867,0.0001413352,0.0001440748,0.00008305649,0.0001576353,0.00009010339,0.0001277085,0.001146689],"category_scores_gemma":[0.00005039876,0.00007302697,0.0001843179,0.0001046328,0.00007343935,0.00008025926,0.00008622886,0.0003054433,0.0002489198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001132549,"about_ca_system_score_gemma":0.0001176579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009254686,"about_ca_topic_score_gemma":0.001767145,"domain_scores_codex":[0.9999607,0.00000782098,0.000004418845,0.00000636176,0.00001173186,0.000009044316],"domain_scores_gemma":[0.999976,0.000005763871,0.000005238859,0.000002870015,0.000003680714,0.000006419953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001589543,0.00005807107,0.0001718129,0.00002668367,0.000005175561,0.00001312797,0.000005762885,0.00008677065,0.9982272,0.00002161075,0.00003999007,0.001184943],"study_design_scores_gemma":[0.00003653204,0.001700325,0.005057031,0.000008019486,0.00002062357,0.0001362181,0.00003013772,0.001006163,0.9901722,0.00002781738,0.001800556,0.000004428608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997368,0.0007069625,0.000363286,0.00003476576,0.00001153665,0.00001808395,0.0004509051,0.00002271103,0.001023704],"genre_scores_gemma":[0.995764,0.0005794723,0.000845361,0.00003663665,0.000004823598,0.00001130045,0.0009028848,0.000006107372,0.001849314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001146689,"threshold_uncertainty_score":0.003836036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02364016690165886,"score_gpt":0.274445211178222,"score_spread":0.2508050442765631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}