{"id":"W3157748039","doi":"10.1210/jendso/bvab048.1363","title":"Infigratinib in Children With Achondroplasia (ACH): Design of PROPEL2 - A Phase 2, Open-Label, Dose-Escalation and Dose-Expansion Study","year":2021,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Endochondral ossification; Internal medicine; Adverse effect; Achondroplasia; Oncology; Endocrinology; Pharmacology; Surgery; Anatomy; Cartilage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003805472,0.001739595,0.002504074,0.0005430427,0.000433818,0.001206889,0.00129775,0.00172678,0.004126838],"category_scores_gemma":[0.001607188,0.0007202424,0.001336499,0.0005230483,0.0009872542,0.001332168,0.000579552,0.003139115,0.001144825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00159485,"about_ca_system_score_gemma":0.002810628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006342031,"about_ca_topic_score_gemma":0.001741006,"domain_scores_codex":[0.9988616,0.0005476298,0.00007290361,0.0001796893,0.0001268263,0.0002115134],"domain_scores_gemma":[0.9991216,0.0001401394,0.0001503287,0.00009617001,0.00008917604,0.0004025945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.710933,0.1312933,0.01023764,0.002197988,0.001818068,0.0008653846,0.0004824986,0.004386836,0.04809928,0.0009823274,0.005088877,0.08361488],"study_design_scores_gemma":[0.4845181,0.4949077,0.007235979,0.00005997768,0.0005851378,0.000541562,0.0001071218,0.001030327,0.004131428,0.0003698042,0.00646512,0.00004765475],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9585907,0.003476176,0.002187954,0.0009654402,0.0002518987,0.02873555,0.002972716,0.0001515667,0.002668071],"genre_scores_gemma":[0.9425082,0.002652163,0.008612509,0.001915939,0.0002974067,0.03705868,0.003134222,0.00007412265,0.003746807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004126838,"threshold_uncertainty_score":0.02012551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03545234083440083,"score_gpt":0.3539791607928874,"score_spread":0.3185268199584865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}