{"id":"W3157803427","doi":"10.3389/fnano.2021.670543","title":"Suppression of Human Coronavirus 229E Infection in Lung Fibroblast Cells via RNA Interference","year":2021,"lang":"en","type":"article","venue":"Frontiers in Nanotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Chapman University; Pharmaceutical Research and Manufacturers of America Foundation","keywords":"RNA interference; Small interfering RNA; Coronavirus; Gene silencing; Biology; Nucleic acid; Viral envelope; Virology; Cell; Fibroblast; Virus; Cell culture; RNA; Cell biology; Coronavirus disease 2019 (COVID-19); Medicine; Transfection; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008937885,0.0001489513,0.0002574092,0.0002379667,0.00002709236,0.000006597271,0.0002228475,0.0004956258,0.00002934002],"category_scores_gemma":[0.00003915253,0.0001627503,0.00006623973,0.0002503727,0.000139401,0.000008393247,0.0002390008,0.0002434549,0.00000331225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004696123,"about_ca_system_score_gemma":0.00005384935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001588386,"about_ca_topic_score_gemma":0.000549804,"domain_scores_codex":[0.9988664,0.00007468816,0.0003447232,0.0003927375,0.00006696062,0.0002544723],"domain_scores_gemma":[0.9994133,0.000005535961,0.0001110666,0.0003808703,0.00006482036,0.0000243794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000796442,0.00008905818,0.04043259,0.00003629153,0.00001808904,0.00002022615,0.00004001891,0.0001098262,0.951221,0.00001944677,0.00156673,0.006367079],"study_design_scores_gemma":[0.0005367242,0.0003056992,0.004157634,0.0001454783,0.000005872765,0.0000103612,0.00007804265,0.000332243,0.9931676,0.000461792,0.0006415464,0.000156948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821386,0.000874365,0.01603601,0.00004780155,0.0005707674,0.0001092955,0.00000916935,0.00001437182,0.0001996197],"genre_scores_gemma":[0.9978355,0.0007196629,0.00104967,0.00003933266,0.00002555654,0.00001782805,0.00005693867,0.00001396544,0.0002415685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04194666,"threshold_uncertainty_score":0.6636765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008574621624094371,"score_gpt":0.251958667050923,"score_spread":0.2433840454268286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}