{"id":"W3157803427","doi":"10.3389/fnano.2021.670543","title":"Suppression of Human Coronavirus 229E Infection in Lung Fibroblast Cells via RNA Interference","year":2021,"lang":"en","type":"article","venue":"Frontiers in Nanotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Chapman University; Pharmaceutical Research and Manufacturers of America Foundation","keywords":"RNA interference; Small interfering RNA; Coronavirus; Gene silencing; Biology; Nucleic acid; Viral envelope; Virology; Cell; Fibroblast; Virus; Cell culture; RNA; Cell biology; Coronavirus disease 2019 (COVID-19); Medicine; Transfection; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003037812,0.0003221142,0.0002653955,0.0001672877,0.0001587803,0.0002949692,0.0002024959,0.0002539694,0.0004989771],"category_scores_gemma":[0.0001463263,0.0001119934,0.0002795524,0.0001293579,0.0001811374,0.0001196879,0.0001350157,0.0003244656,0.0002225381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002097323,"about_ca_system_score_gemma":0.0002029227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007402756,"about_ca_topic_score_gemma":0.001217074,"domain_scores_codex":[0.9997399,0.00005567107,0.00002914326,0.0000513275,0.00008697552,0.00003689634],"domain_scores_gemma":[0.9999273,0.00002811063,0.00001558247,0.00001044464,0.00001169211,0.000006820318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002549863,0.00001228911,0.0000360786,0.00002296191,0.000002373948,0.00003614597,0.00001057498,0.000048398,0.9989194,0.00006968115,0.00002096396,0.0007956586],"study_design_scores_gemma":[0.00000975113,0.0002984892,0.0005694465,0.00000270848,0.000009917467,0.0001212047,0.00001297866,0.0009350846,0.9961314,0.00002458912,0.00188079,0.000003554762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776894,0.002221962,0.0134604,0.0001794124,0.00007292114,0.0002342174,0.0006446352,0.0001379597,0.005359107],"genre_scores_gemma":[0.982381,0.001958065,0.01115146,0.00009017791,0.00001371511,0.0002104335,0.0006643705,0.00002277421,0.003508076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007402756,"threshold_uncertainty_score":0.001669228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008574621624094371,"score_gpt":0.251958667050923,"score_spread":0.2433840454268286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}