{"id":"W3157804315","doi":"10.1007/s11523-021-00813-6","title":"Multicenter, Open-Label, Phase I Study of DSP-7888 Dosing Emulsion in Patients with Advanced Malignancies","year":2021,"lang":"en","type":"article","venue":"Targeted Oncology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Sumitomo Dainippon Pharma Oncology","keywords":"Medicine; Tolerability; Adverse effect; Discontinuation; Internal medicine; Phases of clinical research; Cancer; Dosing; Oncology; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001674625,0.001371896,0.001803588,0.0003514761,0.0004194555,0.0008043415,0.0007682343,0.0008597132,0.002799239],"category_scores_gemma":[0.0009974807,0.0005036703,0.0007857566,0.0004342907,0.0008225353,0.000887725,0.0003536041,0.003069857,0.0008807833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006739605,"about_ca_system_score_gemma":0.001485116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004734383,"about_ca_topic_score_gemma":0.0007907862,"domain_scores_codex":[0.9995546,0.0001931401,0.00002628927,0.0000969208,0.00005460208,0.00007445959],"domain_scores_gemma":[0.9992893,0.0001119949,0.0001619981,0.00006929805,0.00005272878,0.0003145967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6180591,0.1379851,0.01582692,0.0007516209,0.001035839,0.0004150918,0.000611196,0.003877577,0.1028315,0.0002888168,0.004252036,0.1140652],"study_design_scores_gemma":[0.3465169,0.6325609,0.01211568,0.00001911448,0.0002708418,0.0002943759,0.00006289342,0.001337165,0.004446612,0.0001079601,0.002245216,0.00002221302],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950914,0.0008135884,0.0006073101,0.0001776456,0.00005803939,0.001701664,0.0005164462,0.00008205843,0.0009518324],"genre_scores_gemma":[0.9937412,0.0006358914,0.001569762,0.0003658718,0.0001417221,0.001502546,0.0009524024,0.00002405044,0.001066529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002799239,"threshold_uncertainty_score":0.009364426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01280117383212232,"score_gpt":0.3102873812325547,"score_spread":0.2974862074004324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}