{"id":"W3157804315","doi":"10.1007/s11523-021-00813-6","title":"Multicenter, Open-Label, Phase I Study of DSP-7888 Dosing Emulsion in Patients with Advanced Malignancies","year":2021,"lang":"en","type":"article","venue":"Targeted Oncology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Sumitomo Dainippon Pharma Oncology","keywords":"Medicine; Tolerability; Adverse effect; Discontinuation; Internal medicine; Phases of clinical research; Cancer; Dosing; Oncology; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007310595,0.0001382539,0.0002840142,0.00004719582,0.0000500116,0.000008785105,0.000187197,0.0001499795,0.00002254741],"category_scores_gemma":[0.00004460802,0.0001101999,0.00001988482,0.0001976219,0.00005937784,0.000008972369,0.0001932789,0.0001244064,0.000001931405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005452123,"about_ca_system_score_gemma":0.0001266255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005278395,"about_ca_topic_score_gemma":0.0001934698,"domain_scores_codex":[0.9988585,0.000150652,0.0002938164,0.0003562849,0.0001114318,0.0002293769],"domain_scores_gemma":[0.9993517,0.00001333944,0.0001604328,0.0002330735,0.0001850449,0.00005642283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005372811,0.01112513,0.03183972,0.00003135003,0.0001758162,0.00009160088,0.0005926951,0.000605693,0.9249942,0.000005646942,0.0002034669,0.02496189],"study_design_scores_gemma":[0.1498056,0.03891886,0.0468003,0.0002354289,0.0001461412,0.0000119227,0.00305166,0.0001663225,0.7501227,0.00002395886,0.01004643,0.0006706641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981756,0.0006624949,0.00003384923,0.00004355185,0.0002011959,0.0004948695,0.00001367065,0.000005330173,0.0003693875],"genre_scores_gemma":[0.9984815,0.0001184865,0.0008929789,0.0001402164,0.00001962603,0.00003357418,0.0001571792,0.00001671736,0.0001397457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1748714,"threshold_uncertainty_score":0.449382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01280117383212232,"score_gpt":0.3102873812325547,"score_spread":0.2974862074004324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}