{"id":"W3157831827","doi":"10.1016/j.bpj.2021.03.042","title":"Avoidance of protein unfolding constrains protein stability in long-term evolution","year":2021,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Term (time); Protein stability; Protein evolution; Stability (learning theory); Evolutionary biology; Biology; Computer science; Genetics; Physics; Cell biology; Machine learning","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001903168,0.00009614888,0.0001473883,0.0000298263,0.00003505082,0.0000152613,0.00007864728,0.00008279071,0.00001356612],"category_scores_gemma":[0.0001340202,0.00008986388,0.00008695911,0.0001515296,0.00007597535,0.000006590259,0.00003671983,0.0001807386,0.00000155667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003249858,"about_ca_system_score_gemma":0.0001245509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005118867,"about_ca_topic_score_gemma":0.000009856863,"domain_scores_codex":[0.9991968,0.00008010663,0.0002459708,0.0002030414,0.0001065975,0.00016743],"domain_scores_gemma":[0.9995587,0.00000144614,0.00009292048,0.0001625145,0.0001295189,0.00005485403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003978409,0.0001671553,0.001013034,0.00005816803,0.00001472033,0.000008173684,0.00001579433,0.00002727703,0.9971995,0.0001860217,0.000004716072,0.001265691],"study_design_scores_gemma":[0.0003170008,0.00008273714,0.01604194,0.0001031062,0.000005369729,0.00006114675,0.00002058733,0.00001532086,0.9831285,0.00003145361,0.00009394455,0.00009886973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945101,0.0002702204,0.004819365,0.0001065541,0.0001168473,0.0001347225,0.000008368585,0.00000503804,0.00002885262],"genre_scores_gemma":[0.9986514,0.00001966784,0.0007885722,0.000005401765,0.0004471471,0.000005796861,0.00001017461,0.000007878547,0.00006397048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0150289,"threshold_uncertainty_score":0.3664543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008919006061217347,"score_gpt":0.2301965867967946,"score_spread":0.2212775807355773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}