{"id":"W3157883172","doi":"10.1101/2021.04.15.21255498","title":"Human Leukocyte Antigen-C and Haplotypes: Associations with Resistance and Susceptibility to HIV-1 Infection among Serodiscordant Couples in Nigeria","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Science Centre for Human and Animal Health","funders":"Nigerian Institute of Medical Research","keywords":"Serodiscordant; Human leukocyte antigen; Haplotype; Genotype; Allele; Immunology; Biology; Human immunodeficiency virus (HIV); Medicine; Virology; Internal medicine; Genetics; Antigen; Viral load; Gene; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002718561,0.0001900759,0.0002033636,0.0004167711,0.0005952998,0.0004035588,0.0001296981,0.0002766006,0.002071616],"category_scores_gemma":[0.000849036,0.0002176592,0.0001092668,0.0005158296,0.0002527064,0.0001564563,0.0002387456,0.0002701707,0.00009569875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000108765,"about_ca_system_score_gemma":0.0001518196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003036579,"about_ca_topic_score_gemma":0.003744666,"domain_scores_codex":[0.9998048,0.00006965026,0.000021653,0.00004520332,0.00002618209,0.00003245915],"domain_scores_gemma":[0.9996902,0.00009797485,0.0001199644,0.0000178547,0.00002125007,0.00005276453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006871409,0.00003063244,0.9974006,0.0000117702,0.0000131904,0.0002730651,0.0004588515,0.00001258668,0.0004928918,0.00002781208,0.00003647318,0.00117345],"study_design_scores_gemma":[0.000008914693,0.0001402774,0.9938449,0.0000421563,0.00002495243,0.002494644,0.002782759,0.0001448854,0.0001910674,0.00006604824,0.0002549097,0.000004478329],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996566,0.0001307583,0.00001185796,0.00001009567,0.000001901546,0.000002823194,0.00002876013,3.227627e-7,0.0001569236],"genre_scores_gemma":[0.999801,0.00007939174,0.00002787096,0.00001049388,0.000001388936,0.000002274318,0.00001770674,2.42704e-7,0.00005967083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003036579,"threshold_uncertainty_score":0.006930232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01765165921891614,"score_gpt":0.2755591115022347,"score_spread":0.2579074522833186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}