{"id":"W3157903503","doi":"10.1093/hmg/ddab124","title":"Genome-wide association study of cardiac troponin I in the general population","year":2021,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Norwegian Institute of Public Health; National Institutes of Health; Norges Forskningsråd; Academy of Medical Sciences; St. Olavs Hospital Universitetssykehuset i Trondheim; Medical Research Council; Helse Midt-Norge; National Institute for Health and Care Research; Norges Teknisk-Naturvitenskapelige Universitet; Stiftelsen Kristian Gerhard Jebsen; Faculty of Medicine and Health, University of Sydney; University of Michigan","keywords":"Mendelian randomization; Troponin I; Genome-wide association study; Population; Biology; Internal medicine; Myocardial infarction; Biomarker; Biobank; Cardiology; Genetics; Medicine; Single-nucleotide polymorphism; Genotype; Gene; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001660628,0.0003909494,0.000554155,0.0008846628,0.0005396563,0.0005498179,0.0003883209,0.0006777763,0.001719751],"category_scores_gemma":[0.002929142,0.0002417361,0.0006493163,0.001551475,0.0004513476,0.0002194192,0.0004429878,0.0006758383,0.0002200432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002565631,"about_ca_system_score_gemma":0.000324152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008029996,"about_ca_topic_score_gemma":0.006110895,"domain_scores_codex":[0.9984321,0.0005902904,0.0001048435,0.0005463455,0.0002097344,0.0001166913],"domain_scores_gemma":[0.9988198,0.0003106731,0.0003145709,0.0002234677,0.0001368582,0.0001946891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004466795,0.00006481761,0.9923221,0.00002465655,0.00102154,0.0004220776,0.0001183682,0.00008579367,0.002405791,0.00008284441,0.0003925714,0.002612619],"study_design_scores_gemma":[0.00004916209,0.0001099407,0.9988539,0.000003772137,0.0001794396,0.0002809946,0.00003694445,0.0001179297,0.00005733397,0.00005841317,0.0002480376,0.000004134329],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978539,0.0004974464,0.0003837498,0.00011095,0.00002149726,0.00001624908,0.0005763544,0.00001260133,0.0005272367],"genre_scores_gemma":[0.9986801,0.000197789,0.0002864442,0.00007091074,0.00002376207,0.00001568635,0.0005279813,0.000003794494,0.0001934334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008029996,"threshold_uncertainty_score":0.01596653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01345394481238376,"score_gpt":0.2814034625695974,"score_spread":0.2679495177572137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}