{"id":"W3157903503","doi":"10.1093/hmg/ddab124","title":"Genome-wide association study of cardiac troponin I in the general population","year":2021,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Norwegian Institute of Public Health; National Institutes of Health; Norges Forskningsråd; Academy of Medical Sciences; St. Olavs Hospital Universitetssykehuset i Trondheim; Medical Research Council; Helse Midt-Norge; National Institute for Health and Care Research; Norges Teknisk-Naturvitenskapelige Universitet; Stiftelsen Kristian Gerhard Jebsen; Faculty of Medicine and Health, University of Sydney; University of Michigan","keywords":"Mendelian randomization; Troponin I; Genome-wide association study; Population; Biology; Internal medicine; Myocardial infarction; Biomarker; Biobank; Cardiology; Genetics; Medicine; Single-nucleotide polymorphism; Genotype; Gene; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006586052,0.0001475581,0.0002573537,0.00005345609,0.00009287459,0.00002027481,0.000208059,0.0001817014,0.0000121976],"category_scores_gemma":[0.0003249685,0.0001406635,0.0001284111,0.0001983918,0.00001882529,0.000001648991,0.00009934464,0.000120613,0.000002680533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005775774,"about_ca_system_score_gemma":0.00004952693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001103283,"about_ca_topic_score_gemma":0.0003856856,"domain_scores_codex":[0.9977889,0.0008925849,0.0004537731,0.0003355726,0.0002612622,0.0002679252],"domain_scores_gemma":[0.9990063,0.00004562759,0.0002336434,0.0005130905,0.0001681508,0.00003321479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000004275149,0.0002320496,0.8109026,0.000004413155,0.000091406,0.000005266598,0.000281095,0.00273914,0.1853875,0.00004912131,0.0001902825,0.0001128823],"study_design_scores_gemma":[0.0004160886,0.0002749945,0.9931771,0.000002079129,0.00006088622,0.000001057266,0.0006354724,0.00003669758,0.003596816,0.0003116252,0.001344725,0.0001425133],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974864,0.001179732,0.0002217877,0.0001480102,0.00009431488,0.0003197546,0.00001046615,0.000004172227,0.0005353813],"genre_scores_gemma":[0.9980342,0.0001374782,0.0006796336,0.0003282582,0.0001201631,0.00003806334,0.0004092508,0.00002151418,0.0002314447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1822744,"threshold_uncertainty_score":0.5736091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01345394481238376,"score_gpt":0.2814034625695974,"score_spread":0.2679495177572137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}