{"id":"W3157904273","doi":"10.1210/jendso/bvab048.1689","title":"Development of Intranasal Levothyroxine Powder Delivery for Hypothyroidism","year":2021,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Congenital Ear and Nasal Anomalies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Queen Elizabeth II Health Sciences Centre","funders":"","keywords":"Levothyroxine; Chitosan; Particle size; Zeta potential; Differential scanning calorimetry; Nasal administration; Population; Medicine; Chromatography; Materials science; Pharmacology; Chemistry; Nanotechnology; Nanoparticle; Internal medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000182491,0.00009685831,0.0003011441,0.00002051432,0.00007670526,0.000007520321,0.0001124314,0.00003038546,0.00006895766],"category_scores_gemma":[0.0001239607,0.00005998481,0.0006877047,0.0001387648,0.00005779088,0.00005607709,0.00007549471,0.0001901782,0.000001082109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005730677,"about_ca_system_score_gemma":0.0004720135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001632335,"about_ca_topic_score_gemma":0.000006963096,"domain_scores_codex":[0.9990101,0.00001831359,0.000457521,0.00007895783,0.0002772632,0.0001578626],"domain_scores_gemma":[0.9990282,0.00009026632,0.0002102487,0.000133101,0.0004655206,0.00007263576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000647064,0.0007221823,0.005879402,0.0004318254,0.001996576,0.00007994174,0.003501057,0.00001806893,0.9000643,0.0003612647,0.05566471,0.03063358],"study_design_scores_gemma":[0.005054946,0.0002614851,0.03007722,0.0001659793,0.0004185154,0.00119658,0.002430126,0.00006166076,0.8135063,0.000290774,0.1463771,0.000159358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923138,0.002413123,0.0004730327,0.003958551,0.0003503925,0.0001143935,0.000008148791,0.000005422411,0.0003631624],"genre_scores_gemma":[0.9648949,0.0002438777,0.03036684,0.0006634153,0.0003775937,0.000002089469,0.000002805026,0.00001673831,0.003431755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09071235,"threshold_uncertainty_score":0.2446109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0224709221557243,"score_gpt":0.2667946700549811,"score_spread":0.2443237478992568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}