{"id":"W3157994245","doi":"10.1136/annrheumdis-2020-219601","title":"Tofacitinib for the treatment of ankylosing spondylitis: a phase III, randomised, double-blind, placebo-controlled study","year":2021,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":248,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada)","funders":"","keywords":"Tofacitinib; Medicine; Placebo; Ankylosing spondylitis; Adverse effect; Internal medicine; Randomized controlled trial; Janus kinase inhibitor; Gastroenterology; Surgery; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003190015,0.001556258,0.003620707,0.0004610564,0.0005293435,0.001194592,0.001123492,0.00227269,0.006201948],"category_scores_gemma":[0.001549745,0.0007077287,0.001595282,0.0006737396,0.000960956,0.0008849461,0.0002671123,0.00223762,0.0009599618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00073055,"about_ca_system_score_gemma":0.001919348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006644543,"about_ca_topic_score_gemma":0.001719976,"domain_scores_codex":[0.9992324,0.00038893,0.00006721348,0.0001130937,0.00009744945,0.0001009181],"domain_scores_gemma":[0.9991432,0.0001923366,0.0002650782,0.00005635438,0.00009106589,0.0002517426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9434894,0.01413354,0.0008264703,0.002364422,0.00103547,0.0001027735,0.00007880065,0.00031271,0.009640313,0.0001244081,0.001363581,0.0265282],"study_design_scores_gemma":[0.9524792,0.04485045,0.001123627,0.0000501459,0.0002675704,0.00005658875,0.00001115377,0.0001497603,0.0003627715,0.00004117806,0.0005996195,0.000007945227],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.955448,0.02000616,0.001965627,0.00127376,0.0009723259,0.01457589,0.002553668,0.0002312975,0.002973305],"genre_scores_gemma":[0.9621942,0.01438807,0.003590775,0.002406849,0.001266689,0.01147079,0.001725464,0.00003686496,0.002920331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006201948,"threshold_uncertainty_score":0.0207476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09127472958911044,"score_gpt":0.3844357516029048,"score_spread":0.2931610220137943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}