{"id":"W3158014403","doi":"10.4049/jimmunol.2100141","title":"Cutting Edge: TCR-β Selection Is Required at the CD4+CD8+ Stage of Human T Cell Development","year":2021,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Beijing Municipal Natural Science Foundation; Canadian Institute for Telecommunications Research; Canada First Research Excellence Fund; Krembil Foundation; University of Toronto; National Natural Science Foundation of China; National Institutes of Health; Government of Canada; Canadian Cancer Society Research Institute; Sunnybrook Research Institute","keywords":"T-cell receptor; Biology; CD8; RAG2; Negative selection; T cell; Gene rearrangement; Cell biology; Lineage (genetic); Gene; Molecular biology; Genetics; Antigen; Recombination; Genome; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001022009,0.0001787603,0.0001687652,0.0001176815,0.0001094884,0.0004361111,0.0001363142,0.0002676545,0.00335639],"category_scores_gemma":[0.0001074748,0.00009795778,0.0001229967,0.0000864942,0.0001492111,0.0001921932,0.0001917484,0.0006046267,0.0007934338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001404312,"about_ca_system_score_gemma":0.0001735382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002266123,"about_ca_topic_score_gemma":0.0002269516,"domain_scores_codex":[0.9998566,0.00001798032,0.00001432834,0.00004352679,0.00003410796,0.00003351007],"domain_scores_gemma":[0.9998922,0.00001682456,0.00003111727,0.00001406144,0.00001497735,0.00003074442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005580208,0.000007497572,0.0002281616,0.00001848154,0.000001433352,0.00005242585,0.000005927178,0.00001780749,0.9984989,0.00007001545,0.00005307297,0.0009904387],"study_design_scores_gemma":[0.00001346688,0.0001758079,0.007861898,0.00001080501,0.00001489754,0.0008046926,0.0000359495,0.0004304636,0.9851552,0.00007810249,0.005415408,0.000003198679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882973,0.002429371,0.004927145,0.0002834103,0.00006206088,0.00003306739,0.0006982532,0.0002064596,0.003062983],"genre_scores_gemma":[0.995065,0.0004647997,0.001673229,0.0001356517,0.00001639173,0.00001467779,0.0005424609,0.00002768539,0.002060047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00335639,"threshold_uncertainty_score":0.01122826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04041199063807256,"score_gpt":0.3296500912389186,"score_spread":0.289238100600846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}