{"id":"W3158113359","doi":"10.1186/s13024-021-00448-1","title":"Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; McGill University; Douglas Mental Health University Institute","funders":"Ministry of Education, Culture, Sports, Science and Technology; Japan Agency for Medical Research and Development","keywords":"Pathophysiology; Pathological; Mitochondrion; Dementia; Pathology; Medicine; Postmortem studies; Internal medicine; Amyloid (mycology); Alzheimer's disease; Pittsburgh compound B; Disease; Endocrinology; Neuroscience; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007810893,0.0001799995,0.0002795725,0.0000780897,0.00008567754,0.0000670991,0.00004013286,0.00007091055,0.00006077056],"category_scores_gemma":[0.0001354303,0.0001591959,0.00009667168,0.0002122357,0.0001052591,0.00009827771,0.00004603568,0.0001684133,0.00001044895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003437418,"about_ca_system_score_gemma":0.0003348181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003627089,"about_ca_topic_score_gemma":0.00007774373,"domain_scores_codex":[0.9981968,0.0003229303,0.0002983384,0.0004648129,0.0004375364,0.000279551],"domain_scores_gemma":[0.9990171,0.00005265924,0.00005902159,0.0002957827,0.0001725247,0.0004028689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005440271,0.005905425,0.9193352,0.00009441368,0.01494659,0.02734861,0.0004473154,0.0002532709,0.01531467,0.000979326,0.004718601,0.005216311],"study_design_scores_gemma":[0.01022476,0.0008785558,0.9590472,0.0001404876,0.00213603,0.00004498545,0.00002953687,0.00834157,0.01847258,0.0001109804,0.000216336,0.0003570016],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931009,0.004598471,0.00008923443,0.001456615,0.00007560291,0.0004499154,0.00007033131,0.00003602071,0.0001228619],"genre_scores_gemma":[0.9966978,0.0001910028,0.0002016686,0.00171991,0.00009215084,0.00004027404,0.000979642,0.00003216383,0.00004536581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03971198,"threshold_uncertainty_score":0.6491819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04970878967952432,"score_gpt":0.3321306550329434,"score_spread":0.2824218653534191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}