{"id":"W3158113359","doi":"10.1186/s13024-021-00448-1","title":"Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; McGill University; Douglas Mental Health University Institute","funders":"Ministry of Education, Culture, Sports, Science and Technology; Japan Agency for Medical Research and Development","keywords":"Pathophysiology; Pathological; Mitochondrion; Dementia; Pathology; Medicine; Postmortem studies; Internal medicine; Amyloid (mycology); Alzheimer's disease; Pittsburgh compound B; Disease; Endocrinology; Neuroscience; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003630899,0.0004497832,0.0003880977,0.0008675721,0.0003782135,0.0004705471,0.0002081832,0.0003037227,0.001570065],"category_scores_gemma":[0.001099633,0.0002222497,0.0001854155,0.0003750342,0.0002927838,0.0002326192,0.0003594202,0.0002618626,0.0001825805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002495849,"about_ca_system_score_gemma":0.0001095626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00151222,"about_ca_topic_score_gemma":0.001647663,"domain_scores_codex":[0.9998651,0.00002852573,0.00002393753,0.00003657442,0.00002802617,0.00001785547],"domain_scores_gemma":[0.999086,0.00009393369,0.0005350958,0.00004168577,0.00009339737,0.000149814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002225818,0.0001204417,0.9732171,0.00005937599,0.000159747,0.0009806032,0.0002504592,0.00009299546,0.01822796,0.00004543489,0.0001014213,0.004518537],"study_design_scores_gemma":[0.000009698034,0.0001482193,0.9981434,0.000003698849,0.0000254332,0.0009635075,0.0000566311,0.0001189738,0.0004233286,0.00005387743,0.00005048377,0.000002780415],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992561,0.0004209183,0.00009187667,0.0000159189,0.000003186814,0.000005931921,0.00004272996,0.000004090241,0.0001593125],"genre_scores_gemma":[0.9997317,0.00006990762,0.00006451692,0.000005058086,0.00000588719,0.000002549687,0.00005169793,8.25417e-7,0.00006793193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001570065,"threshold_uncertainty_score":0.005252421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04970878967952432,"score_gpt":0.3321306550329434,"score_spread":0.2824218653534191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}