{"id":"W3158145908","doi":"10.1038/s41433-021-01535-9","title":"Natural history of patients with Leber hereditary optic neuropathy—results from the REALITY study","year":2021,"lang":"en","type":"article","venue":"Eye","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"GENSIGHT BIOLOGICS PARIS; Medical Research Council; School of Medicine, Emory University; National Institute for Health and Care Research; Isaac Newton Trust; National Eye Institute; NIHR Cambridge Biomedical Research Centre; Moorfields Eye Charity; Sight Research UK; Thomas Jefferson University; Emory University","keywords":"Leber's hereditary optic neuropathy; Medicine; Optic neuropathy; Visual acuity; Ophthalmology; Retrospective cohort study; Surgery; Optic nerve","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007779062,0.00008419708,0.0001018766,0.000006245582,0.00002718058,0.0000033593,0.0001012653,0.00004849729,0.00004947668],"category_scores_gemma":[0.000181405,0.00005598229,0.00004102129,0.00003499187,0.00005961886,0.000001980271,0.00007141557,0.00009743823,0.000006158677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000140968,"about_ca_system_score_gemma":0.00009524886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001125286,"about_ca_topic_score_gemma":0.0002405445,"domain_scores_codex":[0.9991568,0.0002169809,0.0001573487,0.0002694258,0.0001109343,0.00008855171],"domain_scores_gemma":[0.9993106,0.00002984686,0.00007584535,0.000433519,0.0001226321,0.00002760414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00859996,0.003247419,0.3839204,0.00003304471,0.0005989412,0.0004266982,0.004465724,0.0001759815,0.318796,0.00006136356,0.2766073,0.003067157],"study_design_scores_gemma":[0.003910698,0.0009302471,0.8731667,0.000009966626,0.00007601775,0.000005178558,0.0004068883,0.00001408365,0.005877285,0.00001092842,0.1153808,0.0002111877],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961435,0.0006319624,0.00002984679,0.0001529359,0.001768266,0.0001332835,0.00008398214,0.000005507401,0.00105077],"genre_scores_gemma":[0.9956552,0.000006097775,0.0001193951,0.0004142917,0.0003067149,0.000005004095,0.000536816,0.000009383874,0.00294714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4892464,"threshold_uncertainty_score":0.2282891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01165549753667644,"score_gpt":0.2216855715364812,"score_spread":0.2100300739998048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}