{"id":"W3158145908","doi":"10.1038/s41433-021-01535-9","title":"Natural history of patients with Leber hereditary optic neuropathy—results from the REALITY study","year":2021,"lang":"en","type":"article","venue":"Eye","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"GENSIGHT BIOLOGICS PARIS; Medical Research Council; School of Medicine, Emory University; National Institute for Health and Care Research; Isaac Newton Trust; National Eye Institute; NIHR Cambridge Biomedical Research Centre; Moorfields Eye Charity; Sight Research UK; Thomas Jefferson University; Emory University","keywords":"Leber's hereditary optic neuropathy; Medicine; Optic neuropathy; Visual acuity; Ophthalmology; Retrospective cohort study; Surgery; Optic nerve","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007196321,0.0002116338,0.0002436267,0.0007197747,0.0003179413,0.0004704637,0.000340917,0.0002948956,0.001143838],"category_scores_gemma":[0.00203702,0.000166566,0.0003356924,0.0005391738,0.0002137265,0.0004520941,0.0007095981,0.0002402415,0.000220877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002998527,"about_ca_system_score_gemma":0.0002008069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004544256,"about_ca_topic_score_gemma":0.004320392,"domain_scores_codex":[0.9992963,0.0002476475,0.00008574898,0.0001706386,0.0001003507,0.00009936996],"domain_scores_gemma":[0.9979073,0.0002403238,0.001324667,0.0001205267,0.0001558848,0.0002514834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009857499,0.00001971252,0.9991634,0.000003340449,0.00001698729,0.0001014798,0.00005096879,0.00002020186,0.00009326086,0.000005725071,0.00004175042,0.0003845445],"study_design_scores_gemma":[0.000006655767,0.0001190893,0.9988629,0.000003730994,0.00001464166,0.0005779366,0.0001839853,0.00008415037,0.00003074119,0.000006905626,0.0001051533,0.00000424024],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992546,0.00005988638,0.00003292421,0.000013503,9.709401e-7,0.000004312345,0.0003599021,0.000002461514,0.0002713161],"genre_scores_gemma":[0.9993299,0.00002443291,0.00004844518,0.0000128234,0.000002668106,0.000004762995,0.0005249944,0.000001402452,0.00005062227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004544256,"threshold_uncertainty_score":0.009035587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01165549753667644,"score_gpt":0.2216855715364812,"score_spread":0.2100300739998048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}