{"id":"W3158165938","doi":"10.1016/j.taap.2021.115553","title":"Characterization of human sulfotransferases catalyzing the formation of p-cresol sulfate and identification of mefenamic acid as a potent metabolism inhibitor and potential therapeutic agent for detoxification","year":2021,"lang":"en","type":"article","venue":"Toxicology and Applied Pharmacology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta; University of Alberta","keywords":"Mefenamic acid; Chemistry; Enzyme; Non-competitive inhibition; Metabolism; Sulfotransferase; Recombinant DNA; Biochemistry; Substrate (aquarium); Metabolite; Enzyme kinetics; Sulfation; Pharmacology; Chromatography; Biology; Active site","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001928048,0.0002058448,0.000168729,0.0001771847,0.00008852905,0.0001677178,0.00009830121,0.0001457005,0.0006902697],"category_scores_gemma":[0.0003016905,0.0001000716,0.0002080981,0.0001230177,0.0001410901,0.0001145454,0.00006733112,0.0001873466,0.0002527218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001641949,"about_ca_system_score_gemma":0.0002481172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001551279,"about_ca_topic_score_gemma":0.001486871,"domain_scores_codex":[0.9999307,0.0000156262,0.000007039319,0.00001105838,0.0000161807,0.0000193338],"domain_scores_gemma":[0.9998558,0.00004126789,0.00002581297,0.00002135371,0.00003100807,0.00002477229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002605237,0.00003916544,0.001028358,0.00001485843,0.000009743442,0.00008432605,0.00002389263,0.0001698229,0.9956993,0.0001560883,0.00003232574,0.002481669],"study_design_scores_gemma":[0.00001774887,0.0003537115,0.008987818,0.000002523479,0.00001965335,0.0007796998,0.00002962749,0.00101447,0.9856966,0.00007414176,0.003019664,0.000004354134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919468,0.001036332,0.005865602,0.0001025946,0.00001078749,0.00002956528,0.0004891966,0.00002502772,0.0004942065],"genre_scores_gemma":[0.9906529,0.0007197182,0.00396154,0.00003834365,0.00001243322,0.00001558476,0.002554597,0.00001267103,0.00203231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001551279,"threshold_uncertainty_score":0.003084481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0478711672261613,"score_gpt":0.3618449695363472,"score_spread":0.3139738023101859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}