{"id":"W3158280019","doi":"10.1212/wnl.0000000000012109","title":"Astrocyte Biomarkers in Alzheimer Disease","year":2021,"lang":"en","type":"article","venue":"Neurology","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Astrocyte; Meta-analysis; Biomarker; Medicine; Internal medicine; Glial fibrillary acidic protein; Confidence interval; Oncology; Aquaporin 4; Alzheimer's disease; Pathology; Disease; Biology; Immunohistochemistry; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01821547,0.00190958,0.008809951,0.004897465,0.0004613703,0.002934538,0.001550111,0.001953065,0.005064372],"category_scores_gemma":[0.03238262,0.000972442,0.01879528,0.004863892,0.0005980691,0.001509525,0.001274542,0.001225399,0.0003560144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001719752,"about_ca_system_score_gemma":0.003842723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004800889,"about_ca_topic_score_gemma":0.01084142,"domain_scores_codex":[0.989583,0.005460221,0.002454399,0.0009994194,0.001156082,0.0003468137],"domain_scores_gemma":[0.9809575,0.01314767,0.003418962,0.0006591299,0.001587489,0.0002293475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"observational","study_design_scores_codex":[0.001963589,0.00002590075,0.008636808,0.5389385,0.410166,0.0001340633,0.00009636079,0.0004763936,0.0004305218,0.0006752383,0.003614195,0.03484252],"study_design_scores_gemma":[0.00146014,0.0004255163,0.01729976,0.1369991,0.8271763,0.0002903175,0.0001211533,0.0004811502,0.0003074,0.001792661,0.01359238,0.00005421148],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.002000319,0.9953367,0.0004675399,0.0007210369,0.0003828786,0.0001987036,0.0005466072,0.00001769137,0.0003284459],"genre_scores_gemma":[0.1748972,0.8130512,0.004083347,0.00293441,0.001560615,0.001592849,0.001248736,0.00003138584,0.000600285],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01821547,"threshold_uncertainty_score":0.09633374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01139031113889053,"score_gpt":0.2439952077350951,"score_spread":0.2326048965962046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}