{"id":"W3158280019","doi":"10.1212/wnl.0000000000012109","title":"Astrocyte Biomarkers in Alzheimer Disease","year":2021,"lang":"en","type":"article","venue":"Neurology","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Astrocyte; Meta-analysis; Biomarker; Medicine; Internal medicine; Glial fibrillary acidic protein; Confidence interval; Oncology; Aquaporin 4; Alzheimer's disease; Pathology; Disease; Biology; Immunohistochemistry; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004550796,0.00008341015,0.00008173496,0.00002931316,0.00002218274,0.000007094814,0.00007520333,0.00008445301,0.00008135914],"category_scores_gemma":[0.00004710259,0.00008632519,0.00005557142,0.00007402182,0.00004714627,0.00000139558,0.0000935351,0.00007521318,0.00002106134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001286946,"about_ca_system_score_gemma":0.00007478098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001395262,"about_ca_topic_score_gemma":0.0001049929,"domain_scores_codex":[0.9992612,0.00007834337,0.0001051932,0.0003100929,0.0000444515,0.0002007132],"domain_scores_gemma":[0.9996229,0.000005812069,0.00002202706,0.0002463791,0.00002476286,0.00007816373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00168545,0.0002932588,0.1239799,0.00001022343,0.0001748376,0.001228834,0.00001674791,0.0001414693,0.8562869,0.0005085825,0.003625524,0.01204822],"study_design_scores_gemma":[0.001964106,0.0008858478,0.3508738,0.000006816679,0.00005091658,0.0001182863,0.00001135349,0.0002017292,0.209891,0.0003387615,0.4352548,0.0004025834],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946934,0.00231199,0.00007484052,0.001366435,0.0001567071,0.00006540005,0.000008407274,0.000007881925,0.001314915],"genre_scores_gemma":[0.9964802,0.00008666793,0.0001100414,0.003049366,0.0001186869,0.00001755797,0.00005964395,0.00001331296,0.00006457201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6463959,"threshold_uncertainty_score":0.3520239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01139031113889053,"score_gpt":0.2439952077350951,"score_spread":0.2326048965962046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}