{"id":"W3158351699","doi":"10.1172/jci136459","title":"Frataxin deficiency promotes endothelial senescence in pulmonary hypertension","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Rehabilitation Institute; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute; National Institute on Aging; National Cancer Institute; National Institutes of Health; Agence Nationale de la Recherche; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; American Heart Association","keywords":"Senescence; Pulmonary hypertension; Medicine; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008463113,0.00007307206,0.0002079732,0.00004202862,0.00002696038,0.00001179475,0.00008674923,0.0001997969,0.00002755006],"category_scores_gemma":[0.003367122,0.00006196486,0.0001184785,0.0001196714,0.00009215407,0.000009790391,0.000035649,0.0002382984,0.000008495325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005594148,"about_ca_system_score_gemma":0.0003266496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000333039,"about_ca_topic_score_gemma":0.00001467162,"domain_scores_codex":[0.9984264,0.0003609349,0.0007857041,0.0001834126,0.0001408266,0.0001026974],"domain_scores_gemma":[0.9990658,0.00008412485,0.0003294528,0.0001433757,0.0002753426,0.0001018632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001213261,0.0001246419,0.06002241,0.000008369408,0.000005158378,0.0001340655,0.00001453421,0.00003215161,0.9351814,0.00007473298,0.0005131334,0.003768037],"study_design_scores_gemma":[0.002277119,0.001317778,0.1429715,0.0001735742,0.00004340402,0.002035461,0.0001470245,0.0006797834,0.8280506,0.003769606,0.01824274,0.0002914884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946419,0.000418152,0.002379253,0.0009179751,0.001276957,0.00005181622,0.000002547306,0.000002416092,0.0003089804],"genre_scores_gemma":[0.9903275,0.0003737873,0.006764387,0.001224393,0.001032287,0.00000126527,0.00002308347,0.000007852182,0.0002454276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1071309,"threshold_uncertainty_score":0.4031003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06294846259037065,"score_gpt":0.3283995559301692,"score_spread":0.2654510933397985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}